| Project/Area Number |
10671256
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIMURA Motonobu Osaka University Graduate of Medicine Associant Professor, 医学系研究科, 助手 (90291442)
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| Co-Investigator(Kenkyū-buntansha) |
SAWA Yoshiki Osaka University Graduate of Medicine, Lecturer, 医学系研究科, 講師 (00243220)
OHTAKE Shigeaki Osaka University Graduate of Medicine, Lecturer, 医学系研究科, 講師 (50243209)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1998: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Extracorporeal circulation / Cytokine network / Biocompatible material / Hybrid artificial lung / Plasma discharge / ハイブリット型人工肺 / 血管内皮 / 抗炎症性サイトカイン / prostacyclin / 吸引脱血 / 開心術 |
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| Research Abstract |
Although extracorporeal circulation is a necessary tool for performing open heart sturgery. it still have several problems for clinical use. One of them is the organ dysfunction due to the inflammatory response caused by the extracorporeal circulation. The extracorporeal circulation has the blood contact with artificial surface, which activates the cytokine network and the strong inflammatory response with the elevation of IL-6 and IL-8. This inflammatory response is considered to be one of the causes for the post-operative infection or post-operative organ dysfunction. In this study, we tried to develop the cardiopulmonary bypass circuit with less inflammatory reaction.
First, we tested the circuit coated with new biocompatible material PMEA.From our results, this new coating material has about the same ability as heparin-bonded surface. Moreover, PMEA has the advantage of less-expensiveness and the ability to be coated to almost all the materials. Second, we tried to develop hybrid artificial lung, in which the endothelial cells are seeded on the inner surface of the hollow fibers. Our initial experiment showed that it could decrease inflammatory reaction caused by extracorporeal circulation. Current problem is the efficiency of the cell seeding. Now we are working on this problem using plasma discharge method.
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