| Project/Area Number |
10671266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | 宮崎医科大学 |
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Principal Investigator |
NAKAMURA Kunihide Miyazaki Medical college, faculty of Medicine, Assistant Professer, 医学部, 講師 (10207871)
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| Co-Investigator(Kenkyū-buntansha) |
ONITSUKA Toshio Miyazaki Medical college, faculty of Medicine, Professor, 医学部, 教授 (60108595)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1999: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1998: ¥400,000 (Direct Cost: ¥400,000)
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| Keywords | thoracoabdominal aortic aneurysm / spinal cord ischemia / spinal cord protection / subarahnoid perfusion / adenosine |
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| Research Abstract |
Bacground Spinal cord ischemia with resultant paraplegia is a serious complication after thoracic and thoracoabdominal aortic repair, even nowadays. This study was designed to investigate the effects of KW3345 and dipyridamole, a nucleotide transport inhibitor, on neurological recovery and spinal evoked potentials in a well established rabbit model of spinal cord ischemia during aortic repair.
Method New Zealand white rabbits weighting 2.5-3.0 kg were anesthetized with halothane by an inhalation mask. Spinal cord ischemia was produced by occluding the infra-renal abdominal aorta, iliac bifurcation and caudal-mesenteric artery, a potent collateral cerculation to spinal cord, with a vascular clump for a period of 30 minutes under clean laparotomy. Spinal evoked potentials were continuously recorded with an electrode placed on the posterior portion of the dura at C3 and L3 level after partial laminectomy. The experimental groups were as follows, group 1 : only normal saline was administered. Group2 : KW3345 was administered to infra renal aortic segment during spinal ischemia. Group3 : Dipyridamole was administered to infra-renal aortic segment during spinal ischemia.
Result All animals showed complete paralysis of the hind limbs. Spinal evoked potentials were not monitoered during ischemia in all animals.
Conclusion Administration of nucleotide transport inhibitor through infra-renal aortic segment cannt be used as protection of ischemia of the spinal cord.
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