| Project/Area Number |
10671268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
SHIBATA Toshihiko Osaka City University, Medical, Recturer, 医学部, 講師 (10260803)
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| Co-Investigator(Kenkyū-buntansha) |
SUEHIRO Shigefumi Osaka City University, Medical, Associate Professor, 医学部, 助教授 (90142182)
佐々木 康之 大阪市立大学, 医学部, 助手 (50235280)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | vascular anastomosis / titanium clip / neointima / チタニウムクリップ / 血管器械吻合 / titanium clip / PTFE |
|---|
| Research Abstract |
The vascular closure system(VCS), which uses with non-penetrating clips, was developed for vascular anastomosis. The VCS anastomosis is performed by clipping the everted edges of the approximated vascular walls. The technique of anastomosis is very simple, requiring only 10 minutes. The titanium clips were used for 18 anastomoses with expanded polytetrafluoroethylene (ePTEF) grafts in 8 patients of arteriosclerosis obliterans. The titanium clips were abandoned in 5 of 23 anastomoses (22%) to thickened or calcified vascular walls. There was no evidence of anastomotic rupture, bleeding from the edges, or acute occlusion. The early graft patency was excellent. Two grafts became occluded 14 and 25 months after surgery, respectively. Pathological study showed markedf initimal hyperplasia in the ePTFE side of the anastomotic site. The advantages of the nonpenetrating clips can only be achieved when they are properly applied. Technical errors may cause excess intimal hyperplasia or thrombosis. Long-term follow-up studies are required to demonstrate the efficacy of the VCS for vascular anastomosis.
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