| Project/Area Number |
10671273
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
AOKI Mitsuru Department of Pediatric Cardiovascular Surgery, Tokyo Women's Medical College, Assistant Professor, 医学部, 講師 (80175736)
|
|---|
| Project Period (FY) |
1998 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
|
|---|
| Keywords | Brain / Hemodilution / Cardiopulmonary bypass / Neonate / Infant / Open Heart Surgery / 体外循環 / 心臓 / 手術 / 輸血 |
|---|
| Research Abstract |
Effects of cardiopulmonary bypass with extreme hemodilution (hemoglobin concentrations less than 5.0 g/dl) in pediatric open heart surgery were investigated.
In a animal model using the rabbit undergoing cardiopulmonary bypass, changes in oxygenation levels in intracranial hemoglobin and cytochrome C measured with near-infrared spectroscopy, and histological changes in the hippocampus CA1 area were studied. Yet not decisive the results suggested that the hemoglobin levels over 3.0 g/dl might be safe for cerebral protection during cardiopulmonary bypass. In a clinical study of infants undergoing open heart surgery the changes in oxygenation levels in intracranial hemoglobin and cytochrome C measured with near-infrared spectroscopy and in neurospecific protein S-100 are also investigated. In the study one case that had hemoglobin levels below 3.5 g/dl during moderately hypothermic cardiopulmonary bypass showed transient convulsion and a rise in protein S-100 early after the surgery.
These results suggest that hemoglobin levels above 3.5 g/dl should be maintained during cardiopulmonary bypass in pediatric patients.
|
