| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Research Abstract |
Flow studies are important to understanding pathogenesis and treatment of cerebral aneurysms, but have not been possible in the clinical setting. We have investigated experimentally and clinically intra-aneurysmal bllod flow.
In experiment, we used aneurysms established in and then removed from pigs to compare and correlate flow studies by high-speed video photography of introduced particles and clinically applicable digital subtraction angiography. Mean transit time for contrast in the preparation correlated with video graphically measured particle flow velocity (r=0.616).
In 31 human-aneurysms, aneurysmal blood flow was examined using digital subtraction angiography to determine mean transit time(MTT), the time to peak opacification(PDT) and the time to half-peak(T1/2). Thirty frames per second were acquired and the time density curve was calculated. Regions of interest were drawn on the proximal parent artery, on the distal parent artery, and on the aneurysm itself. In results, MTT of
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the proximal site on the parent artery(P) was 1.82【plus-minus】0.39(second), of the distal site on the parent artery(D) was 2.09【plus-minus】0.51, and of the aneurysm(AN) was 1.91【plus-minus】0.44. PDT of P was 1.39【plus-minus】0.31, of D was 1.56【plus-minus】0.37, and of AN was 1.53【plus-minus】0.38. T1/2 of P was 0.64【plus-minus】0.26, of D was 0.93【plus-minus】0.53, and of AN was 0.83【plus-minus】0.52. MTT of small aneurysm(Sm) was 1.86【plus-minus】0.42, and of large aneurysm(L) was 2.09【plus-minus】0.52. MTT of small aneurysm(Sm) was 1.86【plus-minus】0.42, and of large aneurysm(L) was 2.09【plus-minus】0.52. PDT of Sm was 1.45【plus-minus】0.30, and of L was 1.81【plus-minus】0.53(P=0.23). T1/2 of Sm was 0.75【plus-minus】0.31, and of L was 1.16【plus-minus】0.77(P=0.38). In conclusion, intra-aneurysmal blood flow small aneurysms was similar as that in the parent artery, consequently the central stream strikes the aneurysmal wall. Intra-aneurysmal blood flow in large aneurysms was slower than that in small ameurysms. Less
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