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Hemodynamic effects on the treatment of cerebral aneurysms evaluated using hydraulic vascular model

Research Project

Project/Area Number 10671331
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionOsaka Medical College

Principal Investigator

NAGASAWA Shiro  Faculty of Medicine, Osaka Medical College, Associate Professor, 医学部, 助教授 (10144370)

Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Keywordsaxial flow / basilar artery / cerebral aneurysm / hemodynamics / occlusion therapy / simulation / thrombosis / 後交通動脈
Research Abstract

1, Parent occlusion therapy for basilar head aneurysm.
Using a hydraulic model, half-life of the dye in the model aneurysm was measured as an index of the intraaneurysmal stagnation. The ratio of diameters of the two posterior communicating arteries (PCom) is defined as diameter ratio (DR). Occlusion therapy was simulated in 4 different sites.
Occlusion therapy significantly increased the half-life depending on the occlusion site and DR values with the maximum values of infinite in Type A and 25 sec in Type D. placement of the bypass decreased the tangential flow volume to the aneurysmal neck, and increased the time markedly in Types A and B, considerably in Type C and slightly in Type D.
Parent artery occlusion therapy has been considered less beneficial for the patients with the diameter ratio less than 0.70. Additional bypass placement to the occlusion therapy is very useful in enhancing the aneurysmal stagnation.
2, Characteristics of curvature aneurysms at paraclinoid area.
Hemodynamics of paraclinoid aneurysms were investigated focusing on the effects of their locations and shape of the carotid siphon. Transparent silicon model of the carotid siphon was constructed. When the siphon angle was 0゜, the half-life value was the lowest in the C2-C3 junction aneurysm, highest in the C3 segment aneurysm and intermediate in the C2 segment aneurysm. While the C2-C3 junction aneurysm maintained low values regardless of the angle, the C3 segment aneurysm values decreased and C2 segment aneurysm values increased with increases in the angle. These changes of half-life occur because the point at which the faster moving fluid component strikes the curved wall changes according to the siphon angle.
These results are considered useful to determine the surgical indications, treatment modalities and postsurgical management of the aneurysms.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Shiro Nagasawa: "Simulation of therapeutic parent artery occlusion for basilar aneurysm"Neurological Research. 21. 180-184 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shiro Nagasawa: "Arterial occlusion therapy for basilar and vertebral aneurysm"Journal of Cerebral Blood Flow and Metabolism. 19 Suppl.1. S454 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 長澤史郎: "脳低動脈巨大動脈瘤に対する親動脈閉塞術のモデル解析"Neurological Surgery (脳外). 27. 723-728 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 長澤史郎: "内頚動脈傍床突起動脈瘤の手術成績と留意点"Neurological Surgery (脳外). 27. 809-816 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katsunobu Yamaguchi: "Paraclinoid aneurysms of the internal carotid artery"Neurological Surgery. 21. 733-736 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagasawa S, Sakaguchi I, Ohta T: "The posterior temporal artery as the recipient in superficial temporal artery to posterior cerebral artery bypass. Technical note."Surg Neurol. 52. 73-77 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagasawa S, Kawanishi M, Tada Y, Kawabata S, Ohta T: "Simulation of therapeutic parent artery occlusion for basilar head aneurysms. Hemodynamic effect of occlusion site and diameters of collateral arteries"Neurol Res. 21. 180-184 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagasawa S, Kawabata S, Kawanishi M, Yamaguchi K, Tada Y, Ohta T: "Arterial occlusion therapy for basilar and vertebral aneurysms. Part 2 : Additional techniques to enhance thrombosis"J Cereb Blood Flow Metab. 19. S454 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagasawa S, Kawabata S, Kawanishi M: "Cortical arterial flow volumes in posterior circulation measured by intraoperative Doppler sonography"J Cereb Blood Flow Metab. 19. S581 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamaguchi K, Nagasawa S, Kawabata S, Kawanishi M: "Paraclinoid aneurysms of the internal carotid artery : Hydraulic simulation study on their locations and shape of the carotid siphon"Neurol Res. 21. 733-736 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagasawa S, Kawanishi M, Tada Y, Kawabata S, Ohta T: "Intraoperative measurement of cortical arterial flow volumes in posterior circulation using Doppler sonography"Neurol Res. (to be published).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shiro Nagasawa: "Simulation of therapeutic parent arteny occlution for basilar aneuvysm"Neurological Research. 21. 180-184 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shiro Nagasawa: "Arterial occlusion therapy for basilar and veitebral aneuvysm"Journal of Cuebral Blood Flow and Metabolism. 19 Suppl.1. S454 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 長澤 史朗: "脳底動脈巨大動脈瘤に対する親動脈閉塞術のモデル解析"Neurological Surgery(脳外). 27. 723-728 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 長澤 史朗: "内頚動脈傍床突起動脈瘤の手術成績と留意点"Neurological Surgery(脳外). 27. 809-816 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Katsunobu Yamaguchi: "Paraclinoid aneurysms of the internal carotid artery"Neruological Research. 21. 733-736 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 長澤史朗: "巨大血栓化動脈瘤の治療と模擬実験" 脳卒中-外科. 25. 59-64 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masahiro Kawanishi: "Hemodynamics in an artrial Union" Neurolegical Research. 18. 564-566 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shiro Nagasawa: "Simulation of therapeutic pareut artery occlusion for basilsr head aneurysms to be published" Neurolegical Research. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shiro Nagasawa: "The posterior temporal arteny as the neupient in STA-PCA bypass to bepublished" Surgical Nearology. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shiro Nagasawa: "Hemodyaamic simulation study of cevebral aeteriouenous malformation" Journal of Cevebral Flew and Metabolism. 16. 162-169 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] 長澤史朗: "脳動静奇型の血行動態モデル解析" 脳神経外科. 24. 897-903 (1996)

    • Related Report
      1998 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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