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Basic research on pathophysiology of nerve root

Research Project

Project/Area Number 10671337
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionASAHIKAWA MEDICAL COLLEGE

Principal Investigator

ATSUTA Yuji  Asahikawa Medical College, Orthopedics, associate professor, 医学部, 講師 (90167924)

Co-Investigator(Kenkyū-buntansha) GOTOH Eiji  Asahikawa Medical College,Orthopedics, associate professor, 医学部, 講師 (50142807)
TAKEDA Naoki  Asahikawa Medical College,Orthopedics, associate professor, 医学部, 講師 (80227032)
MATSUNO Takeo  Asahikawa Medical College,Orthopedics, professor, 医学部, 教授 (10165847)
佐藤 雅規  旭川医科大学, 医学部, 助手 (40281886)
猪川 輪哉  旭川医科大学, 医学部, 助手 (00301987)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywordsnerve root / mechanical compression / nucleus pulposus / dorsal root ganglia / ectopic firing / nitric oxide / 髄核 / セロトニン / in vitroモデル
Research Abstract

The purpose of this study is to investigate the functional changes of dorsal root ganglia (DRG) from a view point of ectopic firing after mechanical stimulation, chemical stimulation and application of nucleus pulposus. Adult Wister rats were used. The ectopic firing from DRG was recorded from sural nerve under spinalization.
I. Analysis of the effect of nucleus pulposus on DRG.
The autologous nucleus pulposus was applied to DRG and ectopic firing was observed at 1, 2 and 4 weeks later. High ectopic firing was observed after 1 to 4 weeks after the nucleus pulposus treatment.
II. Effects of mechanical compression and chemical mediator.
The compression of cauda equine was made by silicon tube, then ectopic firing was significantly increased comparing to control animal. When sodium-nitroprussid, which is nitric oxide releaser, was applied to DRG, the animal with cauda compression showed much higher increase of ectopic firing than control animal.
These results demonstrated that mechanical compression, chemical mediator such as nitric oxide and secondary mediators induced by nucleus pulposus contribute to ectopic firing. These phenomena may be related to production of sciatica which is a main symptom of lumbar disc herniation.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Bai YH et al: "Peripheral mononeuropathy induced b loose ligation of the sciatic nerve in the rat"Exp.Animal. 48・2. 87-94 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 佐藤雅規、他: "頚髄症における術後予後予測の試み"日本脊髄外科学会雑誌. 10・1. 72 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 佐藤雅規、他: "後根神経節に対するnitric oxideの影響"北海道整形災害外科学会雑誌. (発表予定).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sato M, Atsuta Y, Takeda N, Ikawa M, Onozawa T, Matsuno T: "Prediction of postoperative results for cervical myelopathy patients using PGEI and electrophysiological parameters."Japanese journal of spine surgery. 10. p72 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Bai YH, Takemitsu M, Atsuta Y, Matsuno T.: "Peripheral mononeuropathy induced by loose ligation of the sciatica nerve in the rat : Behavioral, electrophysiological and histopathologic studies."Exp. Anim.. 48(2). 87-94 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sato M, Atsuta Y, Takeda N, Ikawa M, Onozawa T: "The effect of nitric oxide on dorsal root ganglia"Abstract, 96th Hokkaido Orthopedics and Traumatology. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Bai YH, et al.: "Peripheral mononeuropathy induced by loose ligation of the sciatic nerve in teh rat"Exp.Animal. 48・2. 87-94 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 佐藤雅規、他: "頚髄症における術後予後予測の試み"日本脊椎外科学会雑誌. 10・1. 72 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 佐藤雅規、他: "後根神経節に対するnitric oxideの影響"北海道整形災害外科学会雑誌. 発売予定.

    • Related Report
      1999 Annual Research Report
  • [Publications] 佐藤雅規: "頚髄症に対するPGE1と電気生理学的指標を用いた術後予後予測の試み" 東日本整災誌. 10. 17-21 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小林徹也: "急性脊髄損傷に対するヒアルロン酸を用いた脊髄潅流の効果" 日本パラプレジア医学会雑誌. 11・1. 76-77 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 佐藤雅規: "実験的脊髄損傷においてPGE1-α CDが運動誘発電位に及ぼす影響" 現代医療. 30. 153-158 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 白 躍宏: "坐座骨神経慢性絞扼モデルの電気生理学的・組織学的検討" 日整会誌. 72. S1433 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 佐藤雅規: "後根神経節に対するnitric oxideの影響" 北整災誌. (発表予定). (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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