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Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo

Research Project

Project/Area Number 10671350
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionNiigata University

Principal Investigator

ENDO Naoto  Niigata University School of Medicine, Department of Orthopaedic Surgery, Professor, 医学部, 教授 (10251810)

Co-Investigator(Kenkyū-buntansha) HANYU Tadamasa  Niigata University School of Medicine, Department of Orthopedic Surgery, Associate Professor, 医学部, 助教授 (20189591)
高橋 栄明  新潟大学, 医学部, 教授 (50018397)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsChondromodulin-I / Angiogenesis inhibitor / Tumor suppression / Tumor angiogenesis / 軟骨肉腫 / in situ hybricization / 抗腫瘍作用
Research Abstract

Chondromodulin-I (ChM-I) was previously identified as an angiogenesis inhibitor in cartilage. In this study, we showed that the level of ChM-I transcripts was substantially reduced to 100 or even less in the lower-grade chondrosarcomas, in articular cartilage or other benign cartilaginous tumors. We implanted human chondrosarcoma OUMS-27 cells into the back of nude mice that reproducibly produced tumors with cartilaginous matrix. Tumor-induced angiogenesis was evident when the tumors were excised 30 days after implantation. However, the local administration of recombinant human ChM-I almost completely blocked vascular invasion and tumor growth in vivo. Moreover, ChM-I also inhibited the growth of HT-29 colon adenocarcinoma in vivo, implying its therapeutic potential for solid tumors.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Hayami, Tadashi: "Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo"FEBS Letters. 458. 436-440 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayami, Tadashi: "Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo"FEBS Letters.. 458-3. 436-440 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayami,Tadashi: "Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo"FEBS Letters. 458・3. 436-440 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hayami T.,Endo N.,et al.: "Specific Loss of Chondromodulin-I(ChM-I:Cartilage Derived Angioinhibitory Factor),mRNA and the Suppression of the Growth by Recombinant ChM-I in Chondrosarcoma" Transaction of the 45th Annual Meeting of Orthopaedic Research Society. 24(1). 299 (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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