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Significance of soluble Fas and its related cytokines in serum of rheumatoid arthritis patients.

Research Project

Project/Area Number 10671352
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionGifu University

Principal Investigator

TAKEUCHI Shoji  Gifu University, School of Medicine Professor, 医学部, 教授 (50021473)

Co-Investigator(Kenkyū-buntansha) MORITA Toshiko  Fukui Medical University, School of Medicine Associate Professor, 医学部, 助教授 (30242746)
SAITOH Kunio  Gifu University, School of Medicine Assistant Professor, 医学部・附属病院, 講師 (80262765)
SEISHIMA Mitsuru  Gifu University, School of Medicine Professor, 医学部, 教授 (10171315)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsRheumatoid arthritis / Apoptosis / Soluble Fas / Cytokine / 慢性関節リウマチ(RA)
Research Abstract

Increase of soluble Fas (sFas) have been reported in some inflammatory disease such as rheumatoid arthritis (RA), and has some destructive functions of the joints.
The aim of this study is to assess the relationship between the sFas and its related cytokines in patient with rheumatoid arthritis.
The subjects consisted of 46 RA patients and 155 voluntary healthy subjects. Stage of the patients is stage I (6 cases), II (4), III (21), IV (15). RF and CRP concentrations were measured by LPIA.IL-6, IL-8, sIL-2R concentrations were determined by ELISA.sFAS concentrations was determined by Seishima's method (Clin, Chem, 42 : 1911〜1941, 1996).
sFas concentrations in RA was higher than controls (RA : 3.62±1.01ng/ml, controls : 2.12ng/ml, p<0.001).
There were no significant differences in sFas among each stage and CRP of RA.In contrast, there were significant correlations between sFas and sIL-2R (r=0.567, P<0.001).
These results suggested that sFas might play an important role in RA.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 佐藤正夫: "RA患者におけるトリプトファン代謝産物濃度の検討"中部リウマチ. 30(2). 141-142 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 佐藤正夫: "慢性関節リウマチ患者における膝関節液中IL-18濃度の検討"中部リウマチ. 31(1). 8-9 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 佐藤正夫: "慢性関節リウマチ患者におけるキヌレニンーキノリン酸代謝の亢進"臨床リウマチ. 12(3). 241-247 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Morita.T: "3-Hydroxyanthranilic acid, AL-Tryptophan metabolite, induces apoptosis in monocyte-derived cell stimulated by interferon-γ"Ann,Clin,Biochem.. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] TAKEMURA Masao, et al: "Significance of Soluble Fas in patients with Rheumatoid Arthritis."J Chubu Rheum Assoc. 30 (2). 131-132 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] SATOH Masao, et al: "Serum Kynurenine Concentration in RA Patients."J Chubu Rheum Assoc. 30 (2). 141-142 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] SATOH Masao, et al: "IL-18 Concentration in RA Knee Joint Fluids."J Chubu Rheum Assoc. 31 (1). 8-9 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] MORITA Toshiko, et al: "3-Hydroxyanthranilic Acid, AL-Tryptophan Metabolite, Induces Apoptosis in Monocyte-derived Cell Stimulated by Interferon-γ."Ann Clin Biochem.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 佐藤正夫: "RA患者におけるトリプトファン代謝産物濃度の検討"中部リウマチ. 30(2). 141-142 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 佐藤正夫: "慢性関節リウマチ患者における膝関節液中IL-18濃度の検討"中部リウマチ. 31(1). 8-9 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 佐藤正夫: "慢性関節リウマチ患者におけるキヌレニン-キノリン酸代謝の亢進"臨床リウマチ. 12(3). 241-247 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Morita.T: "3-Hydroxyanthranilic acid, AL-Tryptophan metabolite, induces apoptosis in monocyte-derived cell stimulated by interferon-γ"Ann, Clin, Biochem.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 竹村正男,清島 満,武内章二: "RA患者における可溶性Fas測定の意義"中部リウマチ. 30(2). 131-132 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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