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Gene polymorphisms of sex hormone receptors in patients with osteoarthritis and rheumatoid arthritis.

Research Project

Project/Area Number 10671355
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionShiga University of Medical Science

Principal Investigator

USHIYAMA Toshio  Shiga University of Medical Science, Research Associates, 医学部, 助手 (10263055)

Co-Investigator(Kenkyū-buntansha) INOUE Koji  Shiga University of Medical Science, Associate Professor, 医学部, 助教授 (80213156)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
KeywordsOsteoarthritis / rheumatoid arthritis / estrogen / androgen / gene / polymorphism / Rheumatoid arthritis / Osteoarthritis / Estrogen / Anarogen / gene polymorphism / Androgen / Gene polymorphism
Research Abstract

There are significant sex differences regarding the prevalence and clinical manifestations of osteoarthritis (OA) and rheumatoid arthritis (RA). OA and RA are more likely to occur in women, suggesting the role of sex hormones in the pathogenesis of diseases. In addition, both diseases have genetic components. From these findings, we investigated the association of polymorphisms of sex hormone-related genes with OA and RA patients.
Some variant of estrogen receptor gene is a genetic marker for generalized OA which is one of subtypes of OA (Ushiyama et al. J Rheumatol, 1998). On the other hand, there was no significant association between the vitamin D receptor gene variants and OA of the hand, hip, knee, or polyarticular involvement (Huang et al. Rheumatology 1999).
In patients with RA, some variants of the estrogen receptor gene are related to the onset of female RA in certain age periods, suggesting the role of the interaction between the estrogen receptor gene and serum levels of estrogen at the onset of the disease (Ushiyama et al. Ann Rheum Dis 1999). In contrast, shorter CAG repeats of the androgen receptor gene, presenting high levels of transactivation activity, is related to the onset of male RA during younger ages (Kawasaki et al. Ann Rheum Dis 1999). Shorter CAG repeats were also associated with male patients with ankylosing spondylitis (Mori K et al. Rhematology 2000). Furthermore, CYP17 gene polymorphisms, which are related to serum sex hormone production, are related to onset of RA (Huang et al. Clin Exp Rheumatol 1999).
We demonstrate the gene expression of both estrogen receptor α and β in human articular chondrocytes and the expression levels of both genes were significantly higher in men than in women. These results suggests that estrogen affects cartilage metabolism directly via receptors (Ushiyama et al. Osteoarthritis Cart, 1999).

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report

Research Products

(51 results)

All Other

All Publications (51 results)

  • [Publications] Ushiyama T,Ueyama H,Inoue K,Nishioka J,Ohkubo I,Hukuda S.: "Estrogen receptor gene polymorphism and generalized osteoarthritis."J Rheumatol. 25. 134-7 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Huang J,Ushiyama T,Inoue K,Mori K,Hukuda S.: "Possible association of CYP17 gene polymorphisms with the onset of rheumatoid arthritis."Clin Exp Rheumatol. 17. 721-4 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Inoue K,Ushiyama T,Tani Y,Hukuda S.: "Sociodemographic factors and failure of hip arthroplasty"International Orthopaedics. 23. 330-3 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawasaki T,Ushiyama T,Ueyama H,Inoue K,Mori K,Ohkubo I,Hukuda S: "Polymorphic CAG repeats of the androgen receptor gene and rheumatoid arthritis"Ann Rheum Dis. 58. 500-2 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nabae M,Inoue K,Ushiyama T,Hukuda S: "Gene expressions of antiinflammatory mediators in THR retrieved interfacial membranes"Acta Orthop Scand. 70. 149-54 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nabae M,Inoue K,Ushiyama T,Kawasaki T,Kikuchi K,Hukuda S: "Rheumatoid nodule near the unresurfaced patella in total knee arthroplasty"Jpn J Rheum Joint Surg. 18. 37-40 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ushiyama T,Mori K,Inoue K,Huang J,Nishioka J,Hukuda S: "Association of oestrogen receptor gene polymorphisms with age at onset of rheumatoid arthritis"Ann Rheum Dis. 58. 7-10 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ushiyama T,Ueyama H,Inoue K,Ohkubo I,Hukuda S: "Expression of genes for estrogen receptors αand βin human articular chondrocytes"Osteoarthritis Cart. 7. 560-6 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shichikawa K,Inoue K,Hirota S,Maeda A,Ota H,Kimura M,Ushiyama T,Tsujimoto M: "Changes in the incidence and prevalence of rheumatoid arthritis in Kamitonda"Wakayama,Japan.1965-1996.Ann Rheum Dis. 58. 751-756 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hukuda S,Inoue K,Ushiyama T,Saruhashi Y,Iwasaki A,Hunag J,Maeda A,Nakai M,Li FX,Yang ZQ: "Spinal degenerative lesions and spinal ligamentous ossifications in ancient Chinese populations of The Yellow River Civilization"Int J Osteoarcaeol. 10. 108-24 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Huang J,Ushiyama T,Inoue K,Kawasaki T,Hukuda S: "Vitamin D receptor gene polymorphisms and osteoarthritis of the hand, hip, and knee : a casecontrol study in Japan"Rheumatology. 39. 79-84 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Inoue K,Wicart P,Kawasaki T,Huang J,Ushiyama T,Hukuda S: "Courpied JP.Prevalence of hip osteoarthritis and acetabular dysplasia French and Japanese adults"Rheumatology. 39. 745-8 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mori K,Ushiyama T,Inoue K,Hukuda S: "Polymorphic CAG repeats of the androgen receptor gene in Japanese male patients with ankylosing spondylitis"Rheumatology. 39. 530-2 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawasaki T,Ushiyama T,Inoue K,Hukuda S: "Effects of estrogen on interleukin-6 production in rheumatoid fibroblast-like synoviocytes"Clin Exp Rheumatol. 18. 743-5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 福田眞輔,井上康二,牛山敏夫,猿橋康雄,黄杰,前田晃,李方祥,中井将嗣,片山一道: "古代日本人および古代中国人における脊椎症,脊椎靭帯骨化症有病率"日整会誌. 72. S734 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 川崎拓,井上康二,牛山敏夫,福田眞輔: "X線によらないアメリカリウマチ学会(ACR)変形堰性膝関節症分類基準の検討"リウマチ. 38. 2-5 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 牛山敏夫,井上康二,川崎拓,福田眞輔: "臼蓋形成不全のある股関節症に対し、L型骨頭骨移植術を併用した人工股関節置換術の成績-5〜10年間追跡した28関節から.-"日関外誌. 19. 141-6 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 尾木祐子,牛山敏夫,井上康二,川崎拓,江川雅章,福田眞輔: "全人工膝関節置換術後,大腿骨頚部のsontaneous fractureを生じた慢性関節リウマチの3例"日関外誌. 19. 215-20 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 牛山敏夫: "genetic markerとOA.リウマチ病セミナーIX"永井書店. 280-85 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 牛山敏夫: "慢性関節リウマチの発症と性ホルモン関連遺伝子.近畿リウマチ病研究会講演集"29-38 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 牛山敏夫: "acromegalyのリウマチ症状.リウマチ病セミナーX"永井書店. 97-113 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 牛山敏夫: "骨粗鬆症とselective estrogen receptor modlators.リウマチ病セミナーXI"永井書店. 103-11 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ushiyama T, Ueyama H, Inoue K, Nishioka J, Ohkubo I, Hukuda S.: "Estrogen receptor gene polymorphism and generalized osteoarthritis"J Rheumatol. 25. 134-7 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Huang J, Ushiyama T, Inoue K, Mori K, Hukuda S.: "Possible association of CYP17 gene polymorphisms with the onset of rheumatoid arthritis"Clin Exp Rheumatol. 17. 721-4 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Inoue K, Ushiyama T, Tani Y, Hukuda S.: "Sociodemographic factors and failure of hip arthroplasty."International Orthopaedics. 23. 330-3 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawasaki T, Ushiyama T, Ueyama H, Inoue K, Moth K, Ohkubo I, Hukuda S.: "Polymorphic CAG repeats of the androgen receptor gene and rheumatoid arthritis."Ann Rheum Dis. 58. 500-2 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nabae M, Inoue K, Ushiyama T, Hukuda S.: "Gene expressions of antiinflammatory mediators in THR retrieved interfacial membranes."Acta Orthop Scand. 70. 149-54 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nabae M, Inoue K, Ushiyama T, Kawasaki T, Kikuchi K, Hukuda S.: "Rheumatoid nodule near the unresurfaced patella in total knee arthroplasty"Jpn J Rheum Joint Surg. 18. 37-40 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ushiyama T, Mori K, Inoue K, Huang J, Nishioka J, Hukuda S.: "Association of oestrogen receptor gene polymorphisms with age at onset of rheumatoid arthritis"Ann Rheum Dis. 58. 7-10 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ushiyama T, Ueyama H, Inoue K, Ohkubo I, Hukuda S.: "Expression of genes for estrogen receptors α and β in human articular chondrocytes."Osteoarthritis Cart. 7. 560-6 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shichikawa K, Inoue K, Hirota S, Maeda A, Ota H, Kimura M, Ushiyama T, Tsujimoto M.: "Changes in the incidence and prevalence of rheumatoid arthritis in Kamitonda, Wakayama, Japan, 1965-1996"Ann Rheum Dis. 58. 751-756 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hukuda S, Inoue K, Ushiyama T, Saruhashi Y Iwasaki A, Huang J, Maeda A, Nakai M, Li FX, Yang ZQ.: "Spinal degenerative lesions and spinal ligamentous ossifications in ancient Chinese populations of The Yellow River Civilization"Int J Osteoarcaeol. 10. 108-24 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Huang J, Ushiyama T, Inoue K, Kawasaki T, Hukuda S.: "Vitamin D receptor gene polymorphisms and osteoarthritis of the hand, hip, and knee : a case- control study in Japan."Rheumatology. 39. 79-84 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Inoue K, Wicart P, Kawasaki T, Huang J, Ushiyama T, Hukuda S, Courpied JP.: "Prevalence of hip osteoarthritis and acetabular dysplasia French and Japanese adults"Rheumatology. 39. 745-8 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mori K, Ushiyama T, Inoue K, Hukuda S.: "Polymorphic CAG repeats of the androgen receptor gene in Japanese male patients with ankylosing spondylitis"Rheumatology. 39. 530-2 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawasaki T, Ushiyama T, Inoue K, Hukuda S.: "Effects of estrogen on interleukin-6 production in rheumatoid fibroblast-like synoviocytes."Clin Exp Rheumatol. 18. 743-5 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Huang,J: "Vitamin D receptor gene polymorphisms and osteoarthritis of the hand, hip, and knee : a case-control study in Japan."Rheumatology. 39. 79-84 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kawasaki,T: "Effects of estrogen on interleukin-6 production in rheumatoid fibroblast-like synoviocytes."Clin Exp Rheumatol. 18. 743-745 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mori,K: "Polymorphic CAG repeats of the androgen receptor gene in Japanese male patients with ankylosing spondylitis."Rheumatology. 39. 530-532 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Inoue,K: "Prevalence of hip osteoarthritis and acetabular dysplasia French and Japanese adults."Rheumatology. 39. 745-748 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hukuda,S: "Spinal degenerative lesions and spinal ligamentous ossifications in ancient Chinese populations of The Yellow River Civilization."Int J Osteoareaeol. 10. 108-124 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 牛山敏夫: "臼蓋形成不全のある股関節症に対し、L型骨頭骨移植術を併用した人工股関節置換術の成績-5〜10年間追跡した28関節から-"日本リウマチ・関節外科学会雑誌. 19. 141-146 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 牛山敏夫: "リウマチ病セミナーXI"永井書店. 9 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Toshio Ushiyama: "Association of oestrogen receptor gene polymorphisms with age at onset of rheumatoid arthritis"Ann Rheum Dis. 58. 7-10 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Taku Kawasaki: "Polymorphic CAG repeats of the androgen receptor gene and rheumatoid arthritis"Ann Rheum Dis. 58. 500-502 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Jie Huang: "Possible association of CYP17 gene polymorphisms with onset of rheumatoid arthritis"Clin Exp Rheumatol. 17. 721-724 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Toshio Ushiyama: "Expression of genes for estrogen receptors α and βin human articular chondrocytes"Osteoarthritis Cart. 7. 560-566 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Jie Huang: "Vitamin D receptor gene polymorphisms and osteoarthritis of the hand, hip, and knee: a case-control study in Japan"Rheumatology. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Kanji Mori: "Polymorphic CAG repeats of the androgen receptor gene in Japanese male patients with ankylosing spondylitis"Rheumatology. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Ushiyama T, Mori K, Inoue K et al.: "Association of estrogen receptor gene polymorphisms with age at onzet of rheumatoid arthritis" Annals of Rheumatic Diseases. 58. 7-10 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 牛山敏夫: "リウマチ病セミナーIX" 永井書店, 6 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1999-03-31   Modified: 2016-04-21  

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