| Project/Area Number |
10671370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Department of Physical Therapy, Sapporo Medical University School of Health Sciences |
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Principal Investigator |
AOKI Mitsuhiro Department of Physical Therapy, Sapporo Medical University School of Health Sciences, Associate Professor, 保健医療学部, 助教授 (10159296)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Gen The Second Department of Anatomy, Sapporo Medical University School of Medicine, Professor, 医学部, 教授 (30157747)
OHTANI Seiji Biomedical Research Center Cell and Tissue Structure, Sapporo Medical University School of Medicine, Instructor, 医学部, 助手
OKAMURA Kenji Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Instructor, 医学部, 助手 (80264513)
ISHII Seiichi Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Professor, 医学部, 教授 (20001000)
木村 明彦 札幌医科大学, 医学部, 助手
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | enthesis / rotator cuff tendon / tissue repair / scanning electron microscope / mechanical properties / 腱の再生 / 骨-腱移行部 / 病理組織学 / 走査電子顕微鏡 / 力学的特性 / 肩腱枝 / 修復 |
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| Research Abstract |
Enthesis is an important site of force transmission through tendon to bone, and collagen fibers of tendons insert into bone via fibrocartilage. However, there were few reports in which repair process of injured enthesis was observed. From 1997, we instituted basic research for repair process of enthesis which has characteristic anatomical structure. As a result of this research, repair process of collagen fibers which enter into bone varies according to the surface of bone on which tendon is re-attached. Tendon repair to distal tendon ends restored the four-layered enthesis in the healing period, whereas tendon repair to the calcified fibrocartilage layer considerably delayed fiber development into bone. Fiber connection to cancellous surface developed according to the remodeling of trabecular bone. Based on these results, in clinical settings, the traditional surgical procedure of the rotator cuff into cancellous bone was proved to be reasonable (J Shoulder Elbow Surg, 2001, in press).
Furthermore, to make clear the fine the process of collagen attachment into cancellous bone, we introduced scanning electron microscope observation. In consequence, connection of newly formed collagen fibers into cancellous bone initiated by forming both new collagen fibers and woven bone at two postoperative weeks. At four postoperative weeks, aligned collagen fibers gathered in bundle and connected into woven bone. At six postoperative weeks, collagen bundles became dense and well aligned forming secure connection to bone. This is the first report in which early process of tendon anchoring into cancellous bone was demonstrated (J Orthop Res, 2001, in press).
According to these studies, we observed repair process of tendon into cancellous bone histologically, and realized that good blood supply and adequate tension induced healing process of tendon to bone. In future study, we should consider an ideal method to reconstruct defected tendon close to bone.
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