| Project/Area Number |
10671387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | JIKEI UNIVERSITY |
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Principal Investigator |
TSUJI Michiko Jikei University,School of Medicine,Department of Orthopaedic Surgery,Lecturer, 医学部, 講師 (80207365)
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| Co-Investigator(Kenkyū-buntansha) |
MUKAI Chiemi Jikei University,School of Medicine,Department of Orthopaedic Surgery, Research Assistant, 医学部, 助手 (00307472)
TANAKA Maki Jikei University,School of Medicine,Department of Orthopaedic Surgery, Research Assistant, 医学部, 助手 (00266701)
FUJII Katsuyuki Jikei University,School of Medicine,Department of Orthopaedic Surgery, Professor, 医学部, 教授 (10112856)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | c-fos gene / Rheumatoid arthritis / collagen induced arthritis / コラーゲン関節炎 |
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| Research Abstract |
The present study shows that expression of c-fos in human chondrocytes results in the decrease of endogenous transcription of Type II collagen and the inequality between matrix protease and their inhibitors. Histopathological studies indicates that the expression of c-fos is increased in chondrocytes from patients with rheumatoid arthritis, but not in those with osteoarthritis. Thus, c-fos could be one of the most potential candidates which play a crucial role in the pathogenesis of cartilage destruction in rheumatoid arthritis. Further studies examining the modulation of c-fos expression may provide an effective approach to prevent joint destruction in rheumatoid arthritis patients.
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