| Project/Area Number |
10671411
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
ADACHI Takehiko Kyoto University, Division of Critial Care Medicine, Lecturer, 医学研究科, 講師 (90252428)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Xenon / Nitrous Oxide / Dorsal Horn / Descending Inhibitory System / Analgesia / 脊髄後角 / 下行性抑制系 |
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| Research Abstract |
Xenon (Xe) suppresses wide dynamic range (WDR) neurons in cat spinal cord to a similar extent as nitrous oxide (NィイD22ィエD2O). The antinociceptive action of NィイD22ィエD2O involves the descending inhibitory system. In order to clarify whether the descending inhibitory system is also involved in the antinociceptive action of Xe, we compared the effects of Xe on the spinal cord dorsal horn neurons with those of NィイD22ィエD2O in spinal cord transected cats anesthetized with α-chloralose and urethane. We investigated the change of WDR neuron responses to touch and pinch by both anesthetics. 70% Xe significantly suppressed both touch-and pinch-evoked responses in all 12 neurons. In contrast, 70% NィイD22ィエD2O did not show significant suppression in both touch-and pinch-evoked responses. These results suggest that the antinociceptive action of Xe might not be mediated by the descending inhibitory system, but instead may be produced by direct effect on spinal dorsal horn neurons.
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