| Project/Area Number |
10671442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Saitama Medical School |
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Principal Investigator |
NAGASAKA Hiroshi Saitama Med. Sch., Associate Prof., 医学部, 助教授 (10189110)
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| Project Period (FY) |
1998 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | Spinal cord / Ketamine / WDRneuron |
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| Research Abstract |
Adult cats of both sexes were used in all experiments. The experimental protocol was approved by our Institutional Animal Care and Use Committee and the ethical guidelines for the treatment of animals of the International Association for the Study of Pain were followed. All surgical procedures were performed under halothane - nitrous oxide -oxygen anesthesia. We investigated the effects of ketamine on the activity of WDR neurons in the spinal dorsal horn that was evoked by skin incision in cats. In addition, we studied the effects of pre- and post-administration of ketamine on the maintained phase of the skin incision response. Each dose was a subanesthetic or anesthetic. (3.0 mg kgィイD1-1ィエD1, 10 mg kgィイD1-1ィエD1). Intravenous administered ketamine produced a dose dependent depression of evoked activity that was not significantly greater when drug was administered before skin incision. However, we can't observe a benefit of a clear preemptive effect of ketamine in cat.
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