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Anaylsis of aging process of blood vessels by measuring pulse wave propagation

Research Project

Project/Area Number 10671444
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTeikyo University

Principal Investigator

SUWA Kunio  M.D.School of Medicine Anesthesia Professor, 医学部, 教授 (50010202)

Co-Investigator(Kenkyū-buntansha) ISHIGURO Yoshiki  M.D.School of Medicine Anesthesia Assistant Professor, 医学部, 講師 (40232285)
GOGOH Takahisa  M.D.School of Medicine Anesthesia Associate Professor, 医学部, 助教授 (00256075)
NIIMI Yoshinori  M.D.School of Medicine Anesthesia Associate Professor, 医学部, 助教授 (90198416)
MORITA Shigeho  M.D.School of Medicine Anesthesia Professor, 医学部, 教授 (60143476)
ICHINOSE Fumito  M.D.School of Medicine Anesthesia Assistant Professor, 医学部, 講師 (40276712)
SAEGUSA Hiroaki  M.D.School of Medicine Anesthesia Research Associate (50256070)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsPulse wave propagation / Pulse wave velocity / artificial vessel / R-wave of EKG / Pulse oximeter / thickness of vessel wall / Arteriosclerosis / Diagnosis of Arteriosclerosis / 脈波伝播動特性 / 大動脈波伝播速度 / 脈波伝播時間 / 心電図 / パルスオキシメトリー / 回路シミュレーション / コンピュータシミュレーション / 血管老化度 / 振動系 / 共振 / イナータンス
Research Abstract

This project yielded various new techniques and findings, devising a few methodologies and achieving the following important results.
1) We measured pulse wave propagation along the aorta before and after the replacement of diseased vessel by artificial synthetic vessel. We found that pulse wave propagates considerably more fast along the artificial vessel made of synthetic material than along the original vessels.
2) We devised a simple method of measuring PWV (pulse wave velocity), comparing the initiation of R-wave of EKG with the initiation of finger pulse plethismograph.
3) We verified its usefulness in various experimental protocols. We found PWV may vary in the same place of a single individual, depending upon the different circumstances.
Thickness of the vessel walls has been ignored in analyzing PWV until recently. We hypothesized that the wall thickness plays a crucial role in determining the PWV.We analyzed this theoretically, and proved this factor is quite important in determining the PWV.
5) We analyzed the pulse wave propagation in various models. We proved that the wall thickness and the wall mass should not be ignored.
6) PWV analysis is known to yield occasionally unexpected, faulty results so that pulse wave often travels quite slowly along sclerotic vessels proven in other methods. We conclude that sclerotic vessels often become thick and heavy as well as rigid and less compliant, thereby cancelling the effects on PWV each other.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] 三枝宏彰,新見能成,諏訪邦夫,中西英世,斎藤勇人,森田茂穂: "人工血管置換で大動脈脈波速度は速くなる"麻酔. 41(1). 32-36 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 諏訪邦夫,斎藤勇人,三枝宏彰,市瀬史,中田善規,上園晶一,後藤隆久 他: "仮説:脈波が末梢で拡大するのは共振現象である"麻酔・集中治療とテクノロジー. 1998号. 23-24 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 斎藤勇人,諏訪邦夫,三枝宏彰,市瀬史,中田善規,上園晶一,後藤隆久 他: "「脈波が末梢で拡大するのは共振現象」を回路計算で実証"麻酔・集中治療とテクノロジー. 1998号. 25-26 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 三枝宏彰,諏訪邦夫,斎藤勇人,市瀬史,中田善規,上園晶一,後藤隆久 他: "脈波伝播速度を定めるもう一つの重要な因子として血管壁質量を提案する."麻酔・集中治療とテクノロジー. 1998号. 27-28 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suwa K,Gotoh T,Ishiguro Y,Saito H,Morita H.: "Squeezing the vessel by BP-cuff slows pulse wave transmission"Abstract for the 12th World Congress of Anaesthesiologists.2000, 6.P45.. 2000. 25-25 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kunio Suwa.: "Reproducing the classical research on computer study is easy"Journal of Anesthesia. 14(1). 48-49 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 諏訪邦夫(編): "モニタ機器の使い方と見方.Expert Nurse保存版"照林社/小学館. 225 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 諏訪邦夫(編): "モニタ機器の使い方と見方.エキスパートナースMOOK37"照林社/小学館. 225 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saegusa H, Suwa K et al.: "Pulse wave propagation is faster when a part of aorta is replaced by synthetic material graft."Masui. 48(1). 32-36 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suwa K, Saito H et al.: "Hypothesis : Pulse wave widens toward peripheral vessels because of resonances."Jap J.Soc.Anesthe&Intensive Care. Vol : 1998 (1) : 23-24. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saito H, Suwa K et al.: "Evidence for pulse wave widening toward peripheral vessels by resonances."Jap J.Soc.Anesthe&Intensive Care. Vol : 1998 (1) : 25-26. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saegusa H, Suwa K, et al.: "Proposal of importance of vessel wall thickness for pulse wave propagation."Jap J.Soc.Anesthe&Intensive Care. Vol : 1998 (1) : 27-28. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suwa K.: "Reproducing the classical research on computer study is easy."Journal of Anesthesia. 14. 48-49 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nogami T, Suwa K et al.: "Propofol tends to air bubble, showing up high echo activity."Clin Anesthe (Japan). 24(5). 815-819 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suwa K.: "Mountain climbing, Sao2 and pulse oximetry."Yama-to-Keikoku. 783(10). 151 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suwa K, Gotoh T, Ishiguro Y, Saito H, Morita H.: "Squeezing the vessel by BP-cuff slows pulse wave transmission."Abstract for the 12th World Congress of Anaesthesiologists.. 6. 45 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suwa K (Ed).: "Use of Monitoring Device in Medicine and Nursing"Shorin-sha/Shogakukan, Tokyo. 225 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 三枝宏彰,新見能成,諏訪邦夫,中西英世,斎藤勇人,森田茂穂.: "人工血管置換で大動脈脈波速度は速くなる"麻酔. 41(1). 32-36 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 諏訪邦夫,斎藤勇人,三枝宏彰,市瀬史,中田善規,上園晶一,後藤隆久 他: "仮説:脈波が末梢で拡大するのは共振現象である"麻酔・集中治療とテクノロジー. -1998号. 23-24 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 斎藤勇人,諏訪邦夫,三枝宏彰,市瀬史,中田善規,上園晶一,後藤隆久 他: "「脈波が末梢で拡大するのは共振現象」を回路計算で実証"麻酔・集中治療とテクノロジー. 1998号. 25-26 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 三枝宏彰,諏訪邦夫,斎藤勇人,市瀬史,中田善規,上園晶一,後藤隆久 他: "脈波伝播速度を定めるもう一つの重要な因子として血管壁質量を提案する."麻酔・集中治療とテクノロジー. 1998号. 27-28 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Suwa K,Gotoh T,Ishiguro Y,Saito H,Morita H.: "Squeezing the vessel by BP-cuff slows pulse wave transinission"Abstract for the 12th World Congress of Anaesthesiologists.2000,6 P45. 2000. 25-25 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kunio Suwa.: "Reproducing the classical research on computer study in easy"Journal of Anesthesia. 14(1). 48-49 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 諏訪邦夫(編): "モニタ機器の使い方と見方.Expert Nurse 保存版"照林社/小学館. 225 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 諏訪邦夫(編): "モニタ機器の使い方と見方.エキスパートナースMOOK37"照林社/小学館. 225 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大嶽 浩司: "外部からの血管圧迫が脈波伝播時間に及ぼす影響"第4回日本心臓血管麻酔学会学術大会抄録集. 145 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中元 起力: "脈波伝播は外部からの血管圧迫で遅くなる"日本臨床麻酔学会誌. 8. S335 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 三枝 宏彰: "人工血管置換で大動脈脈波速度は速くなる" 麻酔. 48・1. 32-36 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 諏訪 邦夫: "仮説-脈波が末梢で拡大するのは共振現象である" 麻酔・集中治療とテクノロジー. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] 三枝 宏彰: "脈波伝播速度を定めるもう一つの重要な因子として血管壁質量を提案する" 麻酔・集中治療とテクノロジー. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] 齊藤 勇人: "「脈波が抹梢で拡大するのは共振現象」を回路計算で実証" 麻酔・集中治療とテクノロジー. (in press).

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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