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Prediction of the presence of follicles and development of individualized therapy in premature ovarian failure based on clinical and basic studies

Research Project

Project/Area Number 10671533
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionShiga University of Medical Science

Principal Investigator

TAKAKURA Kenji  Shiga University of Medical Science, Associate Professor, 医学部, 助教授 (10221350)

Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1999: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordspremature ovarian failure / FSH / inhibin / ovulation induction / follicle / 免疫異常
Research Abstract

Objectives Premature ovarian failure (POF) is a hypergonadotropic hypogonadism manifested by secondary amenorrhea in women under 40 years of age. For POF patients who have wish for a baby, it is indispensable to predict the presence of ovarian follicles. If the patient has no follicles, she has no chance to conceive except for the oocyte donation.
Design and Methods Response of serum LH and FSH levels to E/P administration and serum inhibin levels were determined in 24 POF patients. They were compared retrospectively between ovulatory patients and anovulatory patients.
Results Cases with relatively high levels of serum inhibin showed an increase of serum estradiol level during suppression of gonadtropin secretion by estrogen/progestogen (E/P) or GnRH agonist administration. Thus, it was suggested that serum inhibin measurement may be a useful functional indicator of the presence of follicles. In fact, inhibin levels in the ovulatory group were significantly indicator of the presence of follicles. In fact, inhibin levels in the ovulatory group were significantly higher than those in the anovulatory group (inhibin, 1.19 and 0.29 ; α-β inhibin A, 1.20 and 0.29U/ml, respectively). The degree of decrease in basal gonadotropin levels during E/P or increase of serum estradiol levels after E/P administration may be also a useful indicator of the presence of follicles. In the ovulatory group (n=8) serum levels of FSH during E/P administration were significantly lower than those in the anovulatory group (n=16) (6.4 and 20.2 mlU/ml, respectively). Cyclic E/P therapy was successful in ovulation induction in 25% of idiopathic POF patients, which is similar to GnRH agonist / hMG therapy. Cyclic E/P therapy was more favorable in bone and lipid metabolism and financial cost than GnRH agonist / hMG therapy.
Conclusions Response of serum FSH levels to E/P administration and serum inhibin determination may be useful to predict the presence of ovarian follicles in POF patients.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Wakuda, K. et al.: "Embryo-dependent induction of embryo receptivity in the mouse endometrium"J. Reprod. Fertil.. 115・2. 315-324 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akiyama, M. et al.: "Expression of macrophage inflammatory protein-1α(MIP-1α) in human endometrium throughout to menstrual cycle"Br. J. Obstet. Gynaecol.. 106・7. 725-730 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sugie, K. et al.: "Target cells for an immunosuppressive cytokine, glycosylatioh-inhibiting factor"Int. Immunol.. 11・7. 1149-1156 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 高倉賢二: "多嚢胞卵巣症候群-最近の話題"産婦人科の進歩. 50・2. 208-213 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 高倉賢二: "早発卵巣不全"臨床婦人科産科. 53・2. 174-177 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 後藤栄,他: "排卵障害のない不妊症患者に対する排卵誘発の有効性"産婦人科の進歩. 52・1. 1-5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Wakuda, K. Takakura, K. Nakanishi, K. Kita, H. Shi, M. Hirose and Y. Noda: "Embryo-dependent induction of embryo receptivity in the mouse endometrium"J. Reprod Fertil. 115-2. 315-324 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masaya Hirose, Toshio Kimura, Naozumi Mitsuno, Koji Wakuda, Kenji Takakura, Jun Fujita, Yoichi Noda: "DNA flow cytometric quantification and DNA polymorphism analysis in the case of a complete mole with a coexisting fetus"J Assist Reprod Genet. 16-5. 263-267 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Minoru Akiyama, Hidetoshi Okabe, Kenji Takakura, Yoshihide Fujiyama, Yoichi Noda: "Expression of macrophage inflammatory protein-1a (MIP-1a) in human endometrium throughout the menstrual cycle"Br J Obstet Gynaecol. 106-7. 725-730 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sugie K, Tomura T, Takakura K, Kawano T, Taniguchi M, Grey HM, Ishizaka K: "Target cells for an immunosuppressive cytokine, glycosylation-inhibiting factor"Int Immunol. 11-7. 1149-1156 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wakuda, K et al.: "Embryo-dependent induction of embryo receptivity in the mouse endometrium"J. Reprod. Fertil.. 115・2. 315-324 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Akiyama, M et al.: "Expression of macrophage inflammatory protein-1α(MIP-1α) in human endometrium throughout the menstrual cycle"Br. J. Obstet. Gynaecol.. 106・7. 725-730 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sugie, K et al.: "Target cells for an immunosuppressive cytokine, glycosylation-inhibiting factor"Int. Immunol. 11・7. 1149-1156 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 高倉賢二: "早発卵巣不全"臨床婦人科産科. 53・2. 174-177 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 後藤栄、他: "排卵障害のない不妊症患者に対する排卵誘発の有効性"産婦人科の進歩. 52・1. 1-5 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 高倉賢人: "不妊症に対する外来検査法"産婦人科の進歩. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Wakuda et al.: "Embryo-dependent induction of embryo receptivity in the mouse endometrium" J.Reprod.Fertil. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] 高倉賢二: "早発卵巣不全" 臨婦産. 53・2. 174-177 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 後藤 栄 ほか: "不妊症治療と多胎の防止" 産婦治療. 76・3. 325-327 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 石 紅 ほか: "In vitroマウス着床モデルによる脱落膜細胞・胚相互作用の解析" 産婦の進歩. 50・2. 180-194 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 高倉賢二: "多嚢胞卵巣症候群-最近の話題" 産婦の進歩. 50・2. 208-213 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 千葉隆史 ほか: "マトリックスメタロプロテナーゼ(MMPs)に関する最近の動向-婦人科領域特に子宮内膜症との関連-" 産婦の進歩. 50・2. 171-179 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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