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BASIC STUDY FRO IMMUNOLOGICAL ABNORMALITIES SUCH AS NATURAL KILLER CELL ACTIVITY IN THE UTERINE ENDOMETRIUM IN PATIENTS WITH RECURRENT MISCARRIAGES

Research Project

Project/Area Number 10671563
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNAGOYA CITY UNIVERSITY MEDICAL SCHOOL

Principal Investigator

OGASAWARA Mayumi  NAGOYA CITY UNIVERSITY MEDICAL SCHOOL, SENIOR LECTURERER, 医学部, 講師 (30264740)

Co-Investigator(Kenkyū-buntansha) OZAKI Yasuhiko  NAGOYA CITY UNIVERSITY MEDICAL SCHOOL, JUNIOR LECTURERER, 医学部, 助手 (50254280)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsRECURRENT MISCARRIAGE / NK CELL ACTIVITY / PROGESTERONE / ACTIVATED PARTIAL THROMBOPLASTIN TIME / FETAL ABNORMAL KARYOTYPE / LUPUS ANTICOAGULANT / ANTICARDIOLIPIN ANTIBODY / ANTINUCLEAR ANTIBODY / プロゲステロン / 活性トロンボプラスチン時間 / ループコアンチユアグラント / 抗核抗体 / NK細胞 / NO
Research Abstract

Decidual tissue of abortus in 6 patients with unexplained two or more consecutive spontaneous abortion and 16 women with artificial abortion (control) were analyzed. Cases with spontaneous abortion caused by abnormal embryonal karyotype were excluded from analysis. Lymphocytes were separated from each decidual tissue and CDィイD116+56+3-ィエD1 cells were measured. There was no difference of CDィイD116+56+3-ィエD1 cells between patients and controls. Also macrophages were separated from decidual tissue of 6 patients and 5 controls and TGF-β was measured. There was no difference between two groups.
We determined clinically whether a killed streptococcal preparation, a biological response modifier, is as effective as paternal lymphocyte immunotherapy for unexplained recurrent spontaneous abortion therapy. The success rate in the study group was 73.9% (17/23), compared to 75% (254/205) observed for the controls (not significant). Most of the successful cases exhibited low levels of NK cell activity in the peripheral blood. Suppression of NK cell activity by some immunoregulatory mechanism was also found to have potential benefit in terms of a successful pregnancy outcome.
NK cell activity is also associated with mental disorder. It has been reported that stress induce murine abortion. We studied psychosocial factors in 29 couples with two miscarriages. The second miscarriage had a significantly stronger negative impact than the first for both women and their partners. We also found that low neuroticism, low depression scale score and high self-esteem contributed to high NK activity among 61 women with patients.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Aoki K, Ogasawara M: "Psychosocial factors in recurrent miscarriages"Acta Obstet Gnecol Scandinavica. 77. 572-573 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ogawawara M: "Predictive value of serum progesterone levels"Fertil Steril. 69. 977-978 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ogasawara M, Ozaki Y.: "Activated particl thromboplastine time is associated with farther miscarriages"Fertil Steil. 70. 1081-1084 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ogasawara M: "Prevalence of autoantibodies in patients with recurrent miscarriage"An J Reprod Immunol. 41. 86-90 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ogasawara M: "Embryonic karyotype of abortuses in relation of the mumber of previons miscarriage"Fertil Steril. 73. 300-304 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小笠原真弓 尾崎康彦: "反復流死産患者における活性型部分トロンポプラスチン時間の意義"日本産婦人科新生児血液学会誌. 9. 88-89 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ogawasawawa M: "Reproductive Immunology"Guptha SK. 5 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Aoki K. Furukawa T, Ogasawara M, Hori S, Kitamura T: "Psychosocial factors in recurrent miscarriages"Acta Obstet Gynecol Scandinavica. 77. 572-573 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ogasawara M, kajiura S, Katano K, Aoyama T, Aoki K: "Predictive value of serum progesterone levels. Reply of the authors"Fertil Steril 1998. 69. 977-978 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ogasawara M, Aoki K, Katano K, Aoyama T, Ozaki Y, Suzumori K: "Activated partial thromboplastin time is associated with further miscarriages in cases of recurrent fetal loss"Fertil Steril. 70. 1081-1084 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ogasawara M, Aoki K, Katano K, Aoyama T, Kajiura S, Suzumori K: "Prevalence of autoantibodies in patients with recurrent miscarriage"Am J Reprod Immunol. 41. 86-90 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ogasawara M, Aoki K, Okada S, Suzumori K: "Embryonic karyotype of abortuses in relation to the number of previous miscarriage"Fertil Steril. in press. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ogasawara M, Aoki K, Katano K, Aoyama T, Suzumori K: "Clinical significance of β2 glycoprotein I dependent anticardiolipin antibody, lupus anticoagulant and antinuclear antibodies in patients with recurrent miscarriages"In : Reproductive Immunology ed.by Gupta SK Narosa Publishing House, New Delhi, India. 272-276 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Aoki K,Ogasawara M: "Psychosocial factors in recurrent miscarriages"Acta Obstet Gynecol Scanclinavica. 77. 572-573 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ogasawara M: "Predictive value of serum progesterone levels"Fertil Steril. 69. 977-978 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ogasawara M,Ozaki Y.: "Activated partial thromboplastin time is associated with farther miscarriages"Fertil Steril. 70. 1081-1084 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ogasawara M.: "Prevalence of autoantibodies in patients with recurrent miscarriage"Am J Reprod Immunol. 41. 86-90 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ogasawara M: "Embryomic Karyotype of abovtuses in relation of the number of previous miscarriage"Fertil Steril. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小笠原真弓、尾崎康弘: "反復流死産患者における活性型部分トロンボプラスチン時間の意義"日本産婦人科新生児血液学会誌. 9. 88-89 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ogasawara M: "Reproductive Immunology"Gupta SK. (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ozaki Y: "Investigation of NO production by macrophage of decidua in eraly pregnancy from patients with recurrent pregnancy loss." Proceeding of the 12th Annual Meeting of Japan Society for immunology of Reproduction. 25-26 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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