| Project/Area Number |
10671568
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Jichi Medical School |
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Principal Investigator |
MINAKAMI Hisanori Jichi Medical School, Associate Professor, 医学部, 助教授 (40102256)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Takashi Jichi Medical School, Assistant Professor, 医学部, 講師 (90265265)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | twin / HELLP syndrome / thrombocytopenia / liver dysfunction / antithrombin / Pregrancy / fatly liver / disseminated intravascular loagulation |
|---|
| Research Abstract |
We studied prospectively 637 women with singleton pregnancies and 237 women with twin pregnancies to define the clinical features of gestational thrombocytopenia and pregnancy-induced antithrombin III deficiency. Our hypothesis is that women with gestational thrombocytopenia and/or pregnancy-induced antithrombin III deficiency are likely to develop liver dysfunction peripartum. Following results were obtained. Women who exhibited an antenatal gradual declines in platelet count and/or antithrombin III activity were likely to show an elevated perinatal serum level of aspartate aminotransferase. Women with twin pregnancies were more likely to exhibit a gradual declines in platelet count and antithrombin III activity than did women with singleton pregnancies. Serum level of thrombin-antithrombin complex (TAT) was significantly lower in twin than in singleton pregnancies. Antithrombin III activity significantly correlated inversely with serum level of TAT, suggesting that a reduced antithrombin III activity resulted from an enhanced thrombin generation. These results suggest that (1) monitoring of platelet count/antithrombin III activity identifies women at high risk of developing the HELLP syndrome, (2) women with twin pregnancies are more likely to develop the HELLP syndrome than were women with singleton pregnancies, and (3) thrombin generation is increased in twin pregnancies compared with singleton pregnancies.
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