| Project/Area Number |
10671588
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Faculty of Medicine, Shiga University of Medical Science |
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Principal Investigator |
YAZAWA Yoshiro Faculty of Medicine, Shiga University of Medical Science Associate Professor, 医学部, 助教授 (60127040)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Mikio Faculty of Medicine, Shiga University of Medical Science Assistant Professor, 医学部, 講師 (00226557)
KITANO Hiroya Faculty of Medicine, Shiga University of Medical Science Assistant Professor, 医学部, 講師 (20153108)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | endolymhatic hydrops / Meniere's disease / endolymphatic sac / virus / in situ hybridization / vertigo / water regulation / inner ear |
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| Research Abstract |
The objective was to search for a viral etiology in Meniere.s disease by examining the endolymphatic sac specimens. Eight endolymphatic sac(ES)specimens from patients with Meniere's disease and 5 control ES specimens were investigated in this study. 5 control ES specimens include 2 autopsy ES specimens from cases without any pre-mortem ear diseases and 3 ES specimens from acoustic tumor patients. These specimens were studied by in situ hybridization to detect herpes family virus DNA such as herpes simplex virus type 1&2(HSV 1&2), varicella zoster virus(VZV), Epstein-Barr virus(EBV)and human cytomegalovirus(CMV). Of the 8 specimens from the patients with Meniere's disease, 7(88%)were positive for VZV, 5(62%)for EBV, 1(13%)for CMV and none for HSV(1&2), although the serum antibody levels against these viruses did not show significant elevation in these patients just before the ES surgery. Out of the 5 control specimens, 2 showed only slight staining for VZV.This result suggests that the viral DNA in the ES is inactive, however, it is present in a latent form after initial infection. It can be postulated that either VZV or EBV alone or double-infection with both VZV and EBV in early childhood may play a role in the pathogenesis of Meniere's disease.
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