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顔面神経の効果的治療法に関する基礎的研究-神経再生における神経内膜の役割の解明-

Research Project

Project/Area Number 10671601
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNagasaki University

Principal Investigator

NAKAO Yoshiaki  Nagasaki University, assistant Professor, 医学部・附属病院, 講師 (40188884)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Toshimitsu  Nagasaki University, Professor, 医学部, 教授 (80133958)
崎浜 教之  長崎大学, 医学部, 助手 (60264230)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsfacial nerve / endoneurium / nerve edema / vascular permeability / nerve decompression
Research Abstract

(1) Using a fluorescent tracer, the extracelluar fluid pathway in the facial nerve and the diffusion of a tracer from the facial nerve to other cranial naves was examined in the rabbit. The endoneurial connective tissue constitutes a diffusion pathway inside the facial nerve fascicles and the extracelluar fluid pathway from the facial nerve to other cranial ganglia may be related to the neural spread of inflammation.
(2) The diffusion barrier from the peripheral nerve trunk to nerve roots was also examined in the rabbit. The diffusion barrier was located where the cranial nerve pierces the dura mater and arachnoid. The absence of efficient diffusion barrier in peripheral ganglia and their location outside the diffusion barrier seems to be related to the pathogenesis of inflammatory lesions.
(3) Facial nerve paralysis such as Bell's palsy or Ramsay Hunt's syndrome is considered to be entrapment neuropathy due to nerve edema. In order to clarify the mechanism of the nerve edema, the vascul … More ar permeability changes after facial nerve injury was examined in the rabbit. Our study revealed an increased accumulation of fluorescent tracer in the entire nerve on the peripheral side, but not on the central side. In the portion with increased intensity, widening of the endoneurial spaces between nerve fibers was observed. Our findings suggested that changes in the interstitial fluid environment following Wallerian degeneration could increase the endoneurial vascular permeability, and this could then cause endoneurial edema.
(4) In order to clarify the mechanism of the nerve edema due to nerve sheath incision during decompression operation of the facial nerve, the nerve sheath of the normal facial nerve was incised in the rabbit. The facial nerve edema was produced immediately after the incision and the endoneurial vascular permeability increased in the edema portion. Our findings suggested that changes in the interstitial fluid environment due to incision of the perineurial diffusion barrier could increase the endoneurial vascular permeability, and this could then cause endoneurial edema. Less

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 中尾善亮、他: "膝神経節から内耳道に及ぶ顔面神経鞘腫"JOHNS. 14. 753-756 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 崎浜教之、中尾善亮、他: "耳鼻咽喉科領域のヘルペス"LISA. 5. 664-667 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小林俊光、中尾善亮、他: "錐体尖病変の手術"JOHNS. 14. 1245-1252 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中尾善亮、他: "中耳手術へのEr:YAGレーザーの応用"Otol Jpn. 9. 327 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小室哲、中尾善亮、他: "茎状突起骨折に合併した顔面神経麻痺症例"Facial N Res Jpn. 19. 117-118 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中尾善亮: "顔面神経麻痺の部位診断"JOHNS. 15. 319-322 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakao Y, Kobayashi T et al: "Facial nerve neuroma of the temporal bone"JOHNS (Tokyo). 14. 753-756 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sakihama N, Nakao Y, Kobayashi T: "Diagnosis and treatment of Ramsay Hunt's syndrome"LiSA (Tokyo). 5. 664-667 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kobayashi T, Nakao Y et al: "Manipulation of the petrous apex lesions"JOHNS (Tokyo). 14. 1245-1252 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakao Y, Kobayashi T et al: "Use of erbium YAG laser in middle ear surgery"Otol Jpn. 9. 327 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Komuro S, Nakao Y, Kobayashi T et al: "A case of facial nerve paralysis associated with a styloid process fracture."Facial N Res Jpn. 19. 117-118 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakao Y: "Topographic diagnosis of the facial nerve paralysis."JOHNS (Tokyo). 15. 319-322 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中尾善亮、他: "膝神経節から内耳道に及ぶ顔面神経鞘腫"JOHNS. 14. 753-756 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 崎浜教之、中尾善亮、他: "耳鼻咽喉科領域のヘルペス"LlSA. 5. 664-667 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小林俊光、中尾善亮、他: "錐体尖病変の手術"JOHNS. 14. 1245-1252 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中尾善亮、他: "中耳手術へのEr:YAGレーザーの応用"Otol Jpn. 9. 327 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小室哲、中尾善亮、他: "茎状突起骨折に合併した顔面神経麻痺症例"Facial N Res Jpn. 19. 117-118 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中尾善亮: "顔面神経麻痺の部位診断"JOHNS. 15. 319-322 (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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