| Project/Area Number |
10671616
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Tokyo Medical University |
|---|
Principal Investigator |
IMAGAWA Midiri Tokyo Medical University, Medicine, Assistant, 医学部, 助手 (50074646)
|
|---|
| Project Period (FY) |
1998 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
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| Keywords | Fos / vestibular neuron / otolith / guinea pig |
|---|
| Research Abstract |
Signals from vestibular end organs, otolith, and semicircular canals receptors are important for postural and gaze stability. Most of these inputs first terminate in the vestibular nucleus neurons which send the axons to the oculomotor nucleus and spinal cord. The use of Fos protein immunocytochemistry is as a metabolic marcker for indicating neuronal functional activity. We found Fos expression was induced in both side of vestibular nucleus by anesthetization (Nembutal or Ketalar) and electric stimulation of labyrinth. Fos positive vestibular nucleus increased as the vestibular receptors hair cells destroied following intraabdominal injection of aminoglyciside antibiotics (Streptomicin), but no effect on motoneurons in C1-C7 spinal cord segment.
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