| Project/Area Number |
10671626
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Fukuoka University |
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Principal Investigator |
HARADA Hirofumi Fukuoka Univ. Sch. Medicine, Assistant, 医学部, 助手 (00299562)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAISHI Kimio Fukuoka Univ. Sch. Medicine, Assistant, 医学部, 助手 (90187518)
KATO Toshihiko Fukuoka Univ. Sch. Medicine, Professor, 医学部, 教授 (80078766)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Human / Olfactory / Evoked potential / Smell disorder / 誘発反応 / トポグラフィー |
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| Research Abstract |
We developed a device to record olfactory event-related potentials (OERP) from the human scalp. Methlcyclopentenolone was used as the odorant element. A total of 50 stimuli were delivered. Each stimulus lasted 0.5sec and very delivered once every three inspiration. We obtained normal OERP with this device. The positive peak latencies were approximately 350msec (P1) and 700msec (P2), respectively.
In this study, OERP were recorded in 33 patients with smell disorders. A positive response at about 300-400msec was recorded in 7 patients (all females, 15-59 years old). The other 26 patients showed no response. The high potential area of this positive peak was located in the centro-occipital region of the scalp. The latency and the high potential area of this peak were similar to P1 recorded in normal subjects. The source of this was considered identical to that of P1. It may be a response to the trigeminal nerve during odor administration. P2 was not recorded in the patients with smell disorders. P2 may therefore be a response to the olfactory nerve.
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