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Clinical and cell biological investigations into mechanisms of glaucoma induced optic nerve cell death.

Research Project

Project/Area Number 10671635
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

ABE Haruki  Niigata University, School of Medicine, Department of Ophthalmology, Professor, 医学部, 教授 (40018875)

Co-Investigator(Kenkyū-buntansha) FUKUCHI Takeo  Niigata University, University Medical Hospital Assistant, 医学部・附属病院, 助手 (90240770)
SHIRAKASHI Motohiro  Niigata University, School of Medicine, Department of Ophthalmology, Lecturer, 医学部・附属病院, 講師 (50242417)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsrat experimental glaucoma model / blockage of axinal transport / degenerative mitochondria / retinal ganglion cell death / caspase 3 / Scanning laser polarimeter / retinal nerve fiber layer / 網膜神経線維層厚 / 視神経乳頭 / 実験緑内障 / 篩状板 / 形質転換増殖因子 / 神経栄養因子
Research Abstract

The summary of the clinical study : Using a scanning laser polarimeter, we measured the thickness of retinal nerve fiber layer (RNFLT) in 120 eyes of 60 normal subjects. Measurements were made along the peripapillary ring with the diameter of 1.75 disc diameter and another one 0.8 mm away from the disc margin. The RNFLT was not significantly correlated with age along the two rings. However, the RNFLT ratio of total/nasal area significantly decreased with increase in age. There was an increase in the difference of RNFLT between both eyes with increase in age. In spite of interindivividual variations, the RNFLT along both rings showed age-related changes in subjects.
By neurobiological examinations, the experiments using monkey eyes showed that the glaucomatous optic nerve head expressed TGF-β more than that of normal in monkey eyes. This might be related progression of glaucomatous optic disc cupping. The glaucomatous monkey eyes showed lower expression of neurotrophins, NGF, BDNF and CNRF, instead higher expression of Trk B and CNTFR than those in normal eyes. Neurotrophic factors may relate with glaucoma induced optic nerve damage. In addition, degenerative mitochondria with disrupted outer membrane observed in swollen axons and higher expression of caspase 3 in the retinal nerve fiber layer seen in the rat experimental glaucoma model suggested possibility of the release of cytochrome c into cytosol which was known to behave as a critical switch in apoptotic cascade.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Haruki Abe, Shigeru Hasegawa, et al: "Multifocal electroretinogram and visual field defects in patients with glaucoma"Glaucoma Update. VI.. 111-115 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 阿部 春樹: "薬物療法―コンプライアンスをよくするには―improving Compliance with medical Treatment of Glaucoma"あたらしい眼科. 16. 907-912 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 阿部 春樹: "Nerve Fiber Analyzer"眼科. 41. 249-256 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shigeo Funaki, Haruki Abe, et al: "Relationship between age and the thickness of the retinal nerve fiber layer in normal subjects"Jpn J Ophthalmol.. 43. 180-185 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 船木 繁雄、白柏 基宏、阿部 春樹: "正常眼における網膜神経線維層厚の加齢変化"日本眼科学会雑誌. 102. 383-388 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 福地 健郎、阿部 春樹、他6名: "ヒト眼の線維柱帯細胞によるコラーゲンmRNAの発現"日本眼科紀要. 49. 1025-1029 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Motohiro Shirakashi, et al: "Measurement of retinal nerve fiber layer by scanning laser polarimetry and high pass resolution perimetry in normal tension glaucoma with relatively high or low intraocular pressure"Br J Ophthalmol. 83. 353-357 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sawaguchi Shoichi, Haruki Abe, et al: "collagan fibrillar network in the optic nerve head of normal monkey eyes and monkey eyes with laser-induced glaucoma -a scanning electron microscopic"Curr Eye Res. 18. 143-149 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Fukuchi, et al: "Changes in transforming growth factor-beta and platelet-derived growth factor in the optic nerve head in monkey experimental glaucoma"日本眼科学会雑誌. 103. 193-200 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jun Ueda, Haruki Abe: "Experimental Glaucoma Model in the Rat Induced by Laser Trabecular Photocoagulation after an Intracameral Injection of India Ink"Jpn J Ophthalmol.. 42. 337-344 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Haruki Abe, et al.: "Multifocal electroretinogram and visual-field defects in patients with glaucoma."Glaucoma Update. VI. 111-115 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Haruki Abe: "Improving Compliance with medical Treatment of Glaucoma"Journal of the Eye. 16. 907-912 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Haruki Abe: "Nerve Fiber Analyzer"Ganka. 41. 249-256 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Motohiro Shirakashi, Haruki Abe, et al: "Measurement of retinal nerve fiber layer by scanning laser polarimetry and high pass resolution perimetry in normal tension glaucoma with relatively high or low intraocular pressure"Br J Ophthalmol. 83. 353-357 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sawaguchi Shoichi, Haruki Abe, et al: "Collagen fibrillar network in the optic nerve head of normal monkey eyes and monkey eyes with laser-induced glaucoma-a scanning electron microscopic study."Curr Eye Res. 18. 143-149 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Fukuchi, Haruki Abe, et al: "Changes in transforming growth factor-beta and platelet-derived growth factor in the optic nerve head in monkey experimental glaucoma"J Jpn Ophthalmol Soc. 103. 193-200 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shigeo Funaki, Haruki Abe, et al: "Relationship between age and the thickness of the retinal nerve fiber layer in normal subjects"Jpn J Ophthalmol. 43. 180-185 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shigeo Funaki, Haruki Abe, et al: "Relationship between age and the thickness of the retinal nerve fiber layer in normal subjects"J Jpn Ophthalmol Soc. 102. 383-388 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeo Funaki, Haruki Abe, et al: "Collagen mRNA Expression by Human Trabecular Meshwork Cells"Folia Ophthalmol Jpn. 49. 1025-1029 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jun Ueda, Haruki Abe: "Experimental Glaucoma Model in the Rat Induced by Laser Trabecular Photocoagulation after an Intracameral Injection of India Ink."Jpn J Ophthalmol. 42. 337-344 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Haruki Abe, Shigeru Hasegawa, et al.: "Multifocal electroretinogram and visual-field defects in patients with glaucoma"Glaucoma Update. VI. 111-115 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 阿部 春樹: "薬物療法-コンプライアンスをよくするためには-improving Compliance with medical Treatment of Glaucoma"あたらしい眼科. 16. 907-912 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 阿部 春樹: "Nerve Fiber Analyzer"眼科. 41. 249-256 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Motohiro Shirakashi, et al.: "Measurement of retinal nerve fiber layer by scanning laser polarimetry and high pass resolution perimetry in normal tension glaucoma with relatively high or low intraocular pressure"Br J Ophthalmol. 83. 353-357 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sawaguchi Shochi, Haruki Abe, et al.: "Collagen fibrillar network in the optic nerve head of normal monkey eyes and monkey eyes with laser-induced glaucoma - a scanning electron microscopic study"Currr Eye Res. 18. 143-149 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takeo Fukuchi, et al.: "Changes in transforming growth factor-beta and platelet-derived growth factor in the optic nerve head in monkey experimental glaucoma"日本眼科学会雑誌. 103. 193-200 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shigeo Funaki, Haruki Abe, et al.: "Jpn J Ophthalmol"Relationship between age and the thickness of the retinal nerve fiber layer in normal subjects. 6(180-185) (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 福地健郎、阿部春樹、他3名: "サル実験緑内障眼の視神経乳頭部における形質転換増殖因子(TGF)-βと、血小板由来増殖因子(PDGF)の変化" 日本眼科学会雑誌. 103(3). 掲載予定 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 船木繁雄、白柏基宏、阿部春樹: "正常眼における網膜神経維線層厚の加齢変化" 日本眼科学会雑誌. 102(6). 383-388 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 福地健郎、阿部春樹、他6名: "ヒト眼の線維柱帯細胞によるコラーゲンmRNAの発現" 日本眼科紀要. 49(12). 1025-1029 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Jun Ueda,Takeo Fukuchi et al.: "Experimental Glaucoma Model in the Rat Induced by Laser Photocoagulation after an Intracameral Injection of India Ink." Japanese Journal of Ophthalmology. 42. 337-344 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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