| Project/Area Number |
10671642
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Fujita Health University |
|---|
Principal Investigator |
HORIGUCHI Masayuki School of medicine, Fujita Health University professor, 医学部, 教授 (70209295)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYAKE Yozo Nagoya University, School of medicine, professor, 医学部, 教授 (30166136)
嶋津 和弘 名古屋大学, 医学部, 助手 (70293694)
堀尾 直市 名古屋大学, 医学部, 助手 (80293695)
|
|---|
| Project Period (FY) |
1998 – 2000
|
| Project Status |
Completed (Fiscal Year 2000)
|
| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
|
|---|
| Keywords | diabetic retinopathy / multifocal ERG / the first order kernel / the second order kernel / neuropathy / 二次核 / neuropathy / 糖尿病 / 黄斑浮腫 / optical coherent tomography / 硝子体手術 / 網膜厚 / random ERG / 糖尿病黄斑症 |
|---|
| Research Abstract |
We investigated feasibility of multifocal electroretinogram (m-ERG) for diagnosis of diabetic maculopathy. The experiments in animal using glutamate analogues and neurotransmitters revealed that the first order kernel (FOK) originates from the outer layers of the retina and the second order kernel comes (SOK) comes from the inner layers. M-ERG in diabetic patients without retinopathy showed a delay in FOK and a delay and a reduction in SOK.The alteration of SOK was located in the temporal area. These results arise a possibility that early m-ERG changes may be induced by retinal neuropathy which initiates from the temporal area. We found some correlation between m-ERG and the data in photo-stress recovery test which has been found to have some contribution from the inner layers. Finally, we developed a new test, photo-stress recovery test using m-ERG, for further study in diabetic maculopathy.
|
