| Project/Area Number |
10671661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nihon University |
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Principal Investigator |
YUZAWA Mitsuko Dept. of Ophthalmology, Nihon University, school of Medicine, Associate Professor, 医学部, 助教授 (60139160)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Hiroyuki Dept. of Ophthalmology, Nihon University, school of Medicine, Assistant Professor, 医学部, 講師 (40162680)
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| Project Period (FY) |
1998 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2000: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1999: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1998: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | soft drusen / choroidal neovascularization / laser photocoagulation / 加齢黄斑変性 |
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| Research Abstract |
We coagulated soft drusen which was strongly suspected of being predisposed to exudative age-related macular degeneration. During the follow-up period, soft drusen in the macular region disappeared in 14 of the 22 eyes (64%) in the study. Choroidal neovascularization was induced in one of these 14 eyes by photocoagulation. Retinal pigment epitheliumchoriocapillaris atrophy in the fovea developed in another of the 14 eyes. This eye had shown pigmentary change before this foveal atrophy occured We also followed up 98 eyes of 89 patients who met the same eligibility criteria but whose soft drusen was not coagulated. Choroidal neovascularization appeared in 11 eyes (11 %). Accumulative incidence was estimated to be 3% at one year, 39% at three years, and 64% at five years. Although the incidence of developing CNV in untreated eyes is high, the photocoagulation which we performed seems an inappropriate treatment for patients with soft drusen.
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