| Project/Area Number |
10671691
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kansai Medical University |
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Principal Investigator |
KUSUMOTO Kenji K.M. Univ., Dept Plast Surg, Assoc Prof., 医学部, 助教授 (20161630)
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| Co-Investigator(Kenkyū-buntansha) |
AKIOKA Jiro K.M. Univ., Dept Plast Surg, Instructor, 医学部, 助手 (20288799)
OGAWA Yutaka K.M. Univ., Dept Plast Surg, Prof., 医学部, 教授 (70026912)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1998: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Bone morphogenetic protein / osteoinduction / carrier / atelopeptide type I collagen / osteogenesis / skeletal reconstruction / 骨再建 / アテロペプタイドタイプ I コラーゲン / アテロペプタイドタイプIコラーゲン |
|---|
| Research Abstract |
Heterotopic osteoinduction ability of bone morphogenetic protein (BMP) is much anticipated for skeletal reconstruction. Concerning the clinical application of BMP, various promoting agents on the osteoinduction by rhBMP-2 were studied. Those agents were prostaglandin E1, E2, cAMP, calcitonine, K2, O2 and blood supply.
The phalmachological dosage of these agents promoted the osteoinduction. However, high dosage of the agents suppressed the osteogenesis. Those studies showed that each agent acted on the various phases of osteogenesis.
These results suggested adequate dosages of agents in clinical usage of BMP.
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