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Degeneration, regeneration, and transplantation of nerve and muscle

Research Project

Project/Area Number 10671693
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Plastic surgery
Research InstitutionOKAYAMA UNIVERSITY (2000-2001)
Kawasaki Medical School (1998-1999)

Principal Investigator

KOSHIMA Isao  Okayama University, Graduate School of; Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授 (60101804)

Project Period (FY) 1998 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Keywordsmuscle degeneration / muscle regeneration / Pacinian corpuscle / myoblast / myotube / established facial paralysis / vascularized nerve graft / muscle transfer with neurovascular pedicle / 血管柄付神経移植術 / 神経血管柄付筋肉移植術
Research Abstract

Morphological changes of de- and reinnervated Pacinian corpuscles
After denervation of the sciatic nerve, terminal axon of the corpuscles degenerated but outer core exist without degeneration. After reinnervation of the nerve, several terminal axons appeared in the corpuscle.
Muscle de- and regeneration of transferred muscle
After degeneration of muscle, original muscle fibers degenerated to form myobtubes which were developed from myoblasts. After regeneration of thses myotubes, musle cells became normal cytoskeletons.
Clinical investigations of vascularized nerve grafts and vascularized muscle grafts
Clinical usefulness of free vascularized deep peroneal nerve grafts for longer nerve gaps over 20 cm were proved in the cases with brachial plexus palsy. One-stage transfer of free vascularized rectus femoris and abdominis muscle grafts with longer femoral and intercostal motor nerves were clinically proved useful for cases with established facial palsies.

Report

(5 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (83 results)

All Other

All Publications (83 results)

  • [Publications] Isao Koshima, et al.: "Flow-through vascularized toe-joint transfer for reconstruction of segmental loss of an amputated finger"J.Reconstr.Microsurg. 14. 453-458 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Turowski G.A., et al.: "Multiple stapling technique for free muscle transfer to the face"Plast.Reconstr.Surg.. 102. 1639-1641 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 光嶋 勲, 他: "広範囲腹壁欠損に対する腹筋再建"特集 外科・形成外科の連携と展望.臨床外科. 53. 1569-1575 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Isao Koshima, et al.: "Denervation of Pacinian corpuscles : Electron microscopic observations in the rat following nerve transection"J.Reconstr.Microsurg.. 15. 273-279 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Isao Koshima, et al.: "Dynamic reconstruction of the abdominal wall using a reinnervated free rectus femoris muscle transfer"Ann.Plast.Surg.. 43. 199-203 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 光嶋 勲, 他: "血管柄付神経移植の基礎と臨床"骨・関節・靭帯. 13. 933-941 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 光嶋 勲, 他: "癌切除後の顔面神経機能の即時再建"頭頸部腫瘍. 27. 138-141 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koshima Isao, Saisho Hiroshi, Kawada Shinsaku, Hamanaka Takaomi, Umeda Naoto, Moriguchi Takahiko: "Flow-through thin latissimus dorsi perforator flap for repair of soft-tissue defects in the legs."Plast. Reconstr. Surg.. 103(5). 1483-1490 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koshima Isao, Moriguchi Takahiko: "Denervation of Pacinian corpuscles; Electron microscopic observations in the rat following nerve transection."J. Reconstr. Microsurg.. 15(4). 273-279 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koshima Isao, Moriguchi Takahiko, Inagawa Kiichi, Urushibara Katsuyuki: "Dynamic reconstruction of the abdominal wall using a reinnervated free rectus femoris muscle transfer."Ann. Plast. Surg.. 43(2). 199-203 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Isao Koshima, et al.: "Free Tensor Fasciae Latae Perforator Flap for the Reconstruction of Defects in the Extremities"Plastic and Reconstructive Surgery. 107(7). 1759-1765 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Isao Koshima, et al.: "Free Medical Plantar Perforator Flaps for the Resurfacing of Finger and Foot Defects"Plastic and Reconstructive Surgery. 107(7). 1753-1757 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 光嶋 勲 他: "穿通枝皮弁 前外側大腿皮弁"OS NOW. 12. 97-105 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 光嶋 勲 他: "リンパ管外科への挑戦:リンパ浮腫に対する管細静脈吻合術"小児外科. 33(2). 113-118 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 岡 博昭 他: "皮膚扁平上皮癌の統計的検討-特に進行例に関して-"日本形成外科学会会誌. 21(3). 165-171 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Isao Koshima, et al.: "One-Stage Facial Augmentation With an Intraoral Groin Adipose Flap Transfer"Annals of Plastic Surgery. 46(4). 450-453 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 光嶋 勲 他: "リンパ浮腫の治療 保存&外科併用療法"JIM. 11(4). 332-335 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Isao Koshima, et al.: "One-Stage Facial Contour Augmentation with Intraoral Transfer of a Paraumbilical Perforator Adiposal Flap"Plastic and Reconstructive Surgery. 108(4). 988-994 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 光嶋 勲 他: "癌切除後の顔面神経機能の即時再建"頭頸部腫瘍. 27(1). 138-141 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 光嶋 勲 他: "障害者スポーツにおける難治性潰瘍,褥瘡の治療"臨床スポーツ医学. 18(6). 661-667 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 漆原 克之 他: "部分足趾移植による母指再建"川崎医会誌. 27(1). 49-58 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 光嶋 勲 他: "動静脈奇形の部位別治療"形成外科. 44(7). 665-673 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Isao Koshima, et al.: "Free Vascularized Nail Graft under Digital Block"Journal of Reconstructive Microsurgery. 17(8). 599-601 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 稲川喜一 他: "繰り返し瘻孔が再発し.治療に難渋した多発性褥瘡の2例."日形会誌. 20(1). 36-43 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 漆原克之 他: "橈骨動脈穿通皮弁-栄養血管の解剖学的検索."日形会誌. 20(2). 100-103 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koshima Isao, et al.: "Free vascularized appendix transfer for reconstruction of penile urethra with severe fibrosis."The orion Pharma J.Urology.. 2. 16-17 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 光嶋勲 他: "穿通枝皮弁の安全な利用法."形成外科.. 43(3). 229-239 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 岡博昭 他: "Flow-through型前外側大腿皮弁による下腿再建,"日マイクロ会誌.. 13(1). 28-32 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koshima Isao, et al.: "Figertip reconstructions using partial-toe transfers."Plast.Reconsr.Surg... 105(5). 1666-1674 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 稲川喜一 他: "Supramicrosurgeryの有用性."形成外科.. 43(5). 459-466 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 稲川喜一 他: "前額部皮下腫瘍に対する内視鏡下摘出術."川崎医学誌,. 26(2). 101-109 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koshima Isao, et al.: "Invited discussion to "Utilizing free anterolateral thigh flap for reconstruction of head and neck defects folioning cancer ablation"."Plast.Reconstr.Surg.,. 105(7). 2358-2360 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 細田超 他: "頸動脈浸潤癌に対し術前脳血流評価を行った症例の検討."頭頸部腫瘍. 26(1). 133-139 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koshima Isao, et al.: "New Miorosurgical breast reconstruction using free PUP(paraumbilical perforator) adiposal flaps."Plast.Reconstr.Surg.,. 106(1). 61-65 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koshima Isao: "Invited discussion to "Reconstruction of a parotidectomy defects using a paraumbilical perforator flap without deep in ferior epigastric vessels"."Reconstr.Microsurgery.. 16(4). 258-259 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koshima Isao, et al.: "Deep inferior epigastric perforator(DIEP) dermal-fat or adiposal flap for reconstruction of craniofacial contour deformities"Plast.Reconstr.Surg.,. 106(1). 258-259 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koshima Isao, et al.: "New multi-lobed 'accordion' flaps for reconstruction of full-thickness defects in the oral floor."Ann.Plast.Surg.,. 45(2). 187-192 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koshima Isao, et al.: "Supermicrosurgical lymphaticovenular anastomosis for the treatment of lymphedema in : the upper extremities."J.Reconstr.Microsurg.,. 16(6). 437-442 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 光嶋勲: "血管柄付神経移植の基礎と臨床."骨・関節・靭帯,. 13(8). 933-941 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 光嶋勲: "遊離皮弁による頭頸部再建手術."耳鼻咽喉科専門医通信. 64:. 10-11 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 光嶋勲: "乳がん・子宮がん術後の手足の腫れ,リンパ浮腫はどこまで治りますか?腫瘍切除後の組職欠損,機能障害の修復と再建."毎日ライフ.. 31(9). 69-72 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koshima Isao, et al.: "Combined submental flap with toe web for reconstruction of the lip with oral commissure."Br.J.Plast.Surg.,. 53(7). 616-631 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fujiwara keiichi, et al.: "Radiation-induced vesico-vaginal fistula successfully repaired using a gracilis myocutaneous flap."Int.Clin.Oncol.,. 5. 341-344 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 稲川喜一 他: "上顎体の1例."日形会誌.. 20(11). 671-676 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 光嶋勲: "リンパ管外科への挑戦."第82回東京小児外科研究会.ABSTRACTS No.26.. 26. 54-58 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 稲川喜一 他: "腹直筋穿通枝皮弁による頭頸部再建."日頭顎頸外会誌,. 16(3). 26-23 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 光嶋勲: "世界初の"藤本のデルマト-ム"."形成外科,. 43(12)(in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] 新井克志 他: "新女性医学大系6."産婦人科手術の基礎,形成外科.. 14 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koshima Isao: "Free vascularized appendix transfer for reconstructoin of penile urethra with severe fibrosis"Plast.Reconstr.Surg.. 103・3. 964-969 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 光嶋 勲: "再建材料とその採取法,前外側大腿皮弁"耳鼻咽喉科・頭頸部外科. 71・5. 28-34 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Koshima Isao: "Flow-through thin latissimus dorsi perforator flap for repair of soft-tissue defects in the legs"Plast.Reconstr.Surg.. 103・5. 1483-1490 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Koshima Isao: "Denervation of Pacinian corpuscles : Electron microscopic observations in the rat following nerve transection"J.Reconstr.Microsurg.. 15・4. 273-279 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Koshima Isao: "Ear helix flap for reconstruction of total loss of the upper eyelid"Brit.J.Plast.Surg.. 52・4. 314-316 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 白井 博志: "軟部組織内静脈性血管病変(血管腫・血管奇形)に対する経皮的硬化療法の治療成績の検討"日医放射線学会. 59・7. 325-332 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Koshima Isao: "Dynamic reconstruction of the abdominal wall using a reinnervated free rectus femoris muscle transfer"Ann.Plast.Surg.. 43・2. 199-203 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 漆原 克之: "Venous flapを用いた指小欠損修復の経験"川崎医学会誌. 25・2. 113-116 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 光嶋 勲: "リンパ浮腫に対するリンパ管細静脈吻合術"日外科会誌. 100・9. 551-556 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 光嶋 勲: "頭頸部再建における形成再建手術の進歩:合併組織移植,連合皮弁,穿通皮弁などの導入による新たな試み"頭頸部腫瘍. 25・3. 466-470 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Urushibara Katsuyuki: "The radial artery perforator flap : Clinical and anatomical studies. Proceeding 2nd Congress of the Asian Pacific Federation of Societies for Surgery of the Hand"Monduzzi Editore. 2 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Inagawa Kiichi: "Fingertip reconstruction using partial toe transfers. Proceeding 2nd Congress of the Asian Pacific Federation of Societies for Surgery of the Hand"Monduzzi Editore. 2 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Koshima Isao: "Invited Discussion to:“Distal thumb reconstruction with a great toe partial-nail preserving transfer technique"written by Woo Sang-Hyun et al." Plastic and Reconstructive Surgery. 99・1. 120-122 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "穿通皮弁(Perforator Flap)-微小血管外科の進歩と新たな皮弁概念の確立-第1部:その概念と上肢・躯幹部の穿通皮弁." 日本形成外科学会会誌. 18・1. 1-8 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "Klipper-Weber症候群の手術後にMunchausen症候群を呈した1例" 日本形成外科学会会誌. 18・1. 30-33 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "穿通皮弁(Perforator Flap)-微小血管外科の進歩と新たな皮弁概念の確立-第2部:下肢の穿通皮弁" 日本形成外科学会会誌. 18・2. 61-67 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "下肢リンパ浮腫の病像,35症例の病因と病像:とくに片側性から両側性への移行例について" 日本形成外科学会会誌. 18・3. 138-143 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "Acquired periungual finrokeratomaの1症例" 形成外科. 41・5. 479-484 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "指尖再建を要したフッ化水素酸熱傷の1例" 日本熱傷学会会誌. 24・2. 46-52 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲: "合併複合皮弁移植による再建" 医学のあゆみ. 186・8. 433-436 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "微小口径血管付き遊離組織移植" 医学のあゆみ. 186・8. 448-448 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲: "足趾移植について" 日本醫事新報. 3882. 33-36 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koshima Isao: "Venous flaps in surgery of the hand.Arterial-venous,venous-venous,arterial-arterial flaps,and small homodegital island flaps" Atlas of the Hand Clinics. 3・2. 147-162 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koshima Isao,et al.: "Paraumbilical perforator flap without deep inferior epigastric vessels" Plastic and Reconstrucive Surgery. 102・4. 1052-1057 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "Cardner症候群の1例" 日本形成外科学会会誌. 18・10. 552-555 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "褥瘡に対する治療法の選択-島状perforator flapの有用性について-" 形成外科. 41・10. 925-935 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koshima Isao,et al.: "Flow-through vascularized toe-joint transfer for reconstruction of segmental loss of an amputated finger" Journal of Reconstructive Microsurgery. 14・7. 453-458 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koshima Isao,et al.: "Multiple stapling technique for free muscle transfer to the face" Plastic and Reconstructive Surgery. 102・5. 1639-1641 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "人口真皮移植による爪床・爪母欠損の治療" 形成外科. 41・11. 1047-1051 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koshima Isao,et al.: "Free combined anterolateral thigh flap and vascularized fibula for wide,through-and-through oromandibular defects" Journal of Reconstructive Microsurgery. 14・8. 529-534 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "橈骨動脈穿通皮弁-その解剖と臨床応用-" 日本手の外科学会雑誌. 15・3. 407-409 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "広範囲腹壁欠損に対する腹筋再建.特集 外科 形成外科の連携と展望" 臨床外科. 53・13. 1569-1575 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲, 他: "遊離組織移植術による舌根,中咽頭側壁再建後の嚥下機能評価" 頭頚部腫瘍. 24・3. 352-357 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koshima Isao: "Free anterolateral thigh flaps for reconstruction of head and neck defects.Grabb's Encyclopedia of Flaps,2nd,ed." B.Strauch,L.O.Vasconetz,and E.J.Hail-Findlay,eds.Lippincott-Raven,Philadelphia, 497-500 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 光嶋 勲: "骨移植の画像診断.骨疾患の総合画像診断,初版" 森田陸司監修,福永・大塚・曽根編集 金芳堂, 257-265 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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