Identification of the active site for sialogogic peptides
| Project/Area Number |
10671760
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
ABE Kimio Fukuoka Dental College Oral Biochemistry Professor, 歯学部, 教授 (70076016)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Active site / Sialogogues / Tachykinin / NK receptor / Submandibular / Rat / Synthetic / Natural / 催唾剤 / ペプチド / 口腔乾燥症 / フィサレミン / ヘプタペプチド / 構造-活性相関 / 唾液 / 漢方薬 |
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| Research Abstract |
The regulatory roles for salivation by the N-terminal amino acid residues could be very complicated. When the C-terminal heptapeptides has strong activities, the amino acid residues of the N-terminal portion in positions 1 and 2 could serve as the strong inhibitors, whereas they could serve as the activators when the C-terminal heptapeptides are less active or inactive. In addition, the sialogogic activity of the C-terminal heptapeptides could strongly be regulated with the amino acid residues in positions 5, 6 and 8 numbering as in an undecapeptide.
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Report
(3 results)
Research Products
(17 results)
