| Project/Area Number |
10671774
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | Kagoshima University |
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Principal Investigator |
HASEGAWA Hiroko (1999) Kagoshima University, Dental Hospital, Research Associate, 歯学部・附属病院, 助手 (00295271)
奥 猛志 (1998) 鹿児島大学, 歯学部附属病院, 講師 (50194486)
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| Co-Investigator(Kenkyū-buntansha) |
SHIGETA Koki Kagoshima University, Dental Hospital, Research Associate, 歯学部・附属病院, 助手 (10274854)
MARUYAMA Ikuro Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (20082282)
OGURA Tadashi Kagoshima University, Faculty of Medicine, Professor, 歯学部, 教授 (00059362)
福元 偏子 鹿児島大学, 歯学部, 助手 (10305146)
福原 大子 鹿児島大学, 歯学部附属病院, 助手 (00295271)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | TMD / serum / NO / cytokine / MRI |
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| Research Abstract |
The purpose of study was to evaluation the relationship between clinical signs and Nitric Oxide (NO), complete blood count, inflammatory cytokine, and the relationship between inflammatory cytokine and joint effusion, bone changes of condyle in patients with TMJ dysfunction syndrome.
The subjects were 34 females (mean age was 16 years). Clinical signs were lockjaw, pain of temporomandibular joint or muscle of mastication and TMJ sound. Joint effusion was detected by MRI, and bone changes of condyle were detected by tomography.
There was not statistically significant difference between clinical signs and level of NO. And there was not statistically significant difference between level of NO and joint effusion, bone change of condyle. NO levels of patients with bone changes of condyle tended to be higher than that of patients without bone changes of condyle.
IL-1βand IL-6 concentration was under 20pg/ml. Only two patients, TNF-αconcentration was over 20pg/ml. TNF-αconcentration of a girl with bone change of condyle was very high.
These data suggest, that cytokine affects bone change of condyle was detected in blood.
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