| Project/Area Number |
10671795
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
NAGAOKA Shigetaka Kagoshima University, Faculty of Dentistry, Associate Professor, 歯学部, 助教授 (10155913)
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| Co-Investigator(Kenkyū-buntansha) |
KITANO Motoo Kagoshima University, Faculty of Dentistry, Professor, 歯学部, 教授 (10142118)
MATSUSHITA Kenji Kagoshima University, Faculty of Dentistry, Research Associate, 歯学部, 助手 (90253898)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | dentin-pulp / cytokine / サイトカイン |
|---|
| Research Abstract |
In this study, we investigated the behavior of thick slices from human teeth drilled immediately after extraction and cultured from 3 days to 1 month. Results show that the damaged pulp beneath the cavity is able to develop, in vitro, some typical aspects correlated to tissue healing, evidenced by cell proliferation, neovascularization, and the presence of functional cuboidal cells close to the injured area. After 30 days of culture, elongated spindle-shaped cells can be seen aligned along the edges of the relevant dentin walls, whereas sound functional odontoblasts are well-preserved beneath healthy areas. Tissue recovery leads us to believe that such a culture model will be a useful system for testing factors regulating pulp repair.
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