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Experimental Studies in vivo for chitosan-bonded bone filling material.

Research Project

Project/Area Number 10671850
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionMatsumoto Dental Univ.

Principal Investigator

ITO Michio  Matsumoto Dental Univ., Institute for Dental Science, Professor, 総合歯科医学研究所, 教授 (70064681)

Co-Investigator(Kenkyū-buntansha) HIDAKA Yuichi  Matsumoto Dental Univ., Institute for Dental Science, Assistant Professor, 総合歯科医学研究所, 助手 (80288373)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1998: ¥3,100,000 (Direct Cost: ¥3,100,000)
KeywordsBone filling material / chitin-chitosan / hydroxyapatite / DNA / ALPase / 生体吸収性
Research Abstract

Three kinds of bone filling materials were prepared by combining powder, including CaO, CaSiOィイD23ィエD2 and hydroxyapatite (HAP), and chitin and chitosan. The proportion of CaO, CaSiOィイD23ィエD2 and HAP was 4.5%, 6.0% and 89.5%. This powder 0.54g(A), 0.67g(B) and 0.80gc were kneaded with chitin and chitosan sol 2.2g and hardened, respectively. These materials were evaluated in the experiment animal and osteoblastic cells. The purpose of this study was to discuss which materials were most desirable for the bone filling materials. In an animal experiment, tissue reactions were similar in each material and were characterized by granulation tissue formation with inflammation. In the osseous tissue, repairs at defected sites (B and C) and direct relationship between material A and revealed that DNA contents and alkaline phosphatase activity in material A were significantly higher that those in control. Results of this study chitosan sol 2.2g, was most effective for the bone formation.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 森厚二: "ケイ酸カルシウムを添加した骨補填材の培養骨芽細胞様細胞による評価"第33回日本歯科理工学会抄録集. 18. 71 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 森厚二: "キチン・キトサンに関する研究その9.キチン・キトサンを結合材とする骨補填材のCaSiO_3添加に関する実験的研究"日本口腔インプラント学会誌. 12. 185-192 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Koji Mori, Yuichi Hidaka, Mitsuharu Nakajima, Toru Onizawa, Hiroshi Yagasaki, Kazuo Suzuki, Toshio Igarashi and Michio Ito: "Studies on chitin and chitsan Part 9.Experimental studies on CaSiOィイD23ィエD2 added chitin and chitsan-bonded bone filling materials : The evaluation in the experimental animal and cultured cell"Journal of Japanese Society of Oral Implantology. Vol.12 No.2. 185-192 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 森厚ニ: "キチン・キトサンに関する研究その9.キチン・キトサンを結合材とする骨補填材のCaSiO_3添加に関する実験的研究"日本口腔インプラント学会誌. 12. 185-192 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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