| Project/Area Number |
10671863
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyusyu Dental College (2000-2001)
Akita University (1998-1999) |
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Principal Investigator |
TAKAHASHI Tetsu Kyusyu Dental College, School of Dentistry, Professor, 歯学部, 教授 (60226850)
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| Co-Investigator(Kenkyū-buntansha) |
本間 英孝 秋田大学, 医学部, 助手 (70292381)
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| Project Period (FY) |
1998 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2000: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | temporomandibular disorders / internal derangement / mechanical stress / synovial fluid / synovial fluid analysis / cytokine / nitric oxide / hyaluronic acid / フリーラジカル / 滑膜炎 / 炎症性メディエーター / iNOS / IL-1β / 顎関節鏡 / inducible nitric oxide synthase / 軟骨変性 |
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| Research Abstract |
The purpose of this study is to biochemically analyze the levels of cytokines and nitric oxides in the synovial fluid from patients with patients with internal derangement of the temporomandibular joint, and to investigate the relationship between the mechanical stress such as bruxism and the levels of proinflammatory mediators in the synovial fluid. It was extremely difficult in synovial fluid sampling from the patients with internal derangement and bruxism. Therefore, we could not directly compare the levels of proinflammatory mediators and the presence of mechanical stress. However, We demonstrated that the synovial levels of protein were correlated with joint effusion. In addition, inducible nitric oxide synthase was expressed in the synovial lining cell layers in the synovium of the patients with temporomandibular diseases, not from the control patients. Furthermore, the molecular weight of the hyaluronic acid in the synovial fluid was decreased compared with that of the controls. These biochemical data strongly suggested that mechanical stress in involved in the pathogenesis of the temporomandibular joint diseases such as internal derangement.
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