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Analysis for Prostaglandin E2 and Vascular Endothelial Growth Factor in the Articular Disc and Synovial Cell in case of Internalderangement of the Temporomandibular Joint

Research Project

Project/Area Number 10671872
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

FUJITA Shigeyuki  Kyoto University, Postgraduateschool of Medicine, Assosiate Professor, 医学研究科, 講師 (50228996)

Co-Investigator(Kenkyū-buntansha) YASUDA Shinnya  Kyoto University, Postgraduateschool of Medicine, Assistant Professor, 医学研究科, 助手 (50263075)
MURAKAMI Ken-ichiro  Kyoto University, Postgraduateschool of Medicine Assosiate Professor, 医学研究科, 助教授 (00174269)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1999: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsVEGF / COX-1 / Substance-P / Synovial membrane / Prostaglandin E / Immunohisto chemistry / Temporomandibulac joint / Synovial cell / Immunchistochemistry / Temporomandibular Joint / Synovial cell / Prosta glandin E_2 / シクロオキシゲナーゼ-1 / シクロオキシゲナーゼ-2 / 顎関節内障 / 滑膜細胞 / 細胞培養 / IL-1β / V-cadherin
Research Abstract

In Anatomy institute, Tubingen university Germany, I researched the relation between the variation of the path way on lateral-pterygoid muscle and deformity of the articulator-disc, as the result of this research, there was no significance between them. But in the completely deformed articulator disc, high concentration of keratan-sulfate and chondroitin-6 sulfate wereidentified in the antero-inferior part of the disc and hyperplastic synovial membrane was identified in these cases.
In the completely deformed articulator disc of clicical internalderangement cases, Tenascin was recognized in the hyperplastic synovial membrane and Matrix Metaro Protease-3 also found in the disc, which means remodeling and reproduction were occurred in the same time. In such cases, Substance-P and COX-1 were distributed near the vascular vessels in the hyperplastic synovial membrane, and Localization of Heat-Schock Protein-47 (HSP-47) was also specific in the antero-inner part of the disc, but the HSC-70 was identified in roard bearing part of the disc. We also established the synovial cell line from internalderangement cases, with the stimulation of Inter-leukin-1b (1ng/ml), the cell line autocrined Vascular

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] SHIgeyuki Fujita: "Variation of heads of lateral pterygoid muscle and morpholy of articular disc of human Temporomandibular joint"Journal of Oral Rehabilitation. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] SHIgeyuki Fujita: "Localization of keratan sulfate and chondroitine sulfate on the anterior-displaced Human Temporomandibular Jopnt"Journal of Oral Rehabilitation. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroaki Yoshida: "The expression of Substance P on Human Temporomandibular Joint sample : an immano histochemical study"Journal of Oral Rehabilitation. 26. 338-344 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroaki Yoshida: "The localization of Matrix Metalloproteinase-3 and Tenascin in synovial membrane of the temporomandibula joint"Oral Disease. 5. 50-54 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroaki Yoshida: "The distribution of cycloxygenase-1 human Temporo mandibular joint samples"Journal of Oral Rehabilitation. (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroaki Yoshida: "Angiogenesis in the human temporamandibular Joint studied by immunohistchemistry for CD34 antigen"Journal of Oral Rathology and Pral Medicine. 28. 289-292 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujita S.Iizuka T.Dauber W.: "Variation of heads of lateral pterygoid muscle and morphology of articular disc of human temporomandibular joint-anatomical and histological analysis"J Oral Rehabil. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fujita S.IizukaT.Dauber W.: "Localization of Keratan sulfate and Chondroitin-6-sulfate on the anteriorly-displaced Human Temporomandibular Joint Disc-histological and immunohistological analysis"J Oral Rehabilitation. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshida H, Fujita S, Nishida M, Iizuka T: "The expression of substance P in human temporomandibular joint sample;an immunohistochemical study"J Oral Rehabil. 26. 338-344 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshida H, Yoshida T, Iizuka T, Sakakura T.Fujita S: "The Localization of matrix metalloproteinase-3 and tenascin in the synovial membrane of the temporomandibular joint with internal derangement"Oral Dis. 5. 50-54 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshida H, Yoshida T.Iizuka T, Sakakura T.Fujita S: "The distribution of cycloxygenase-1 human temporomandibular joint samples"J Oral Rehabil. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshida H, Fujita S.Yoshida T.Iizuka T, Sakakura T: "Angiogenesis in human temporomandibular joint studied by immunohistochemistry for CD34 antigen"Journal of Oral Pathology and Oral Medicine. 28. 289-292 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shigeyuki Fujita: "Variation of heads of lateral pterygoid muscle and morphology of articular disc of human Temporomandibular joint"Journal of Oral Rehabilitation. (In press). (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shigeyuki Fujita: "Localization of Keratan Sulfate and Chondroitive Sulfate on the anteriorly-displaced Human Temporomendibular Joint Disc"Journal of Oral Rehabilitation. (In press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroaki Yoshida: "The expression of substance P on Human Temporomandibular Joint samples : an immunohistochemical study"Journal of Oral Rehabilitation. 26. 338-344 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroaki Yoshida: "The localization of matrix metalloproteinose-3 and Tenoscin in synorial membrane of the temporomandibular Joint"Oral Disease. 5. 50-54 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroaki Yoshida: "The distribution of cycloxygenase-1 in human Temporomandibular joint samples"Journal of Oral Rehabilitation. (In press). (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroaki Yoshida: "Angiogenesis in the human temporomandibular Joint studied by immunohistochemistry for CD34 antigen"Journal of Oral Pathology and Oral Medicine. 28. 289-292 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiroaki Yoshida: "Histological and immcnchistochemical staining of the disc inpaltent with poorly functonal tempormandibular joint" Jpn J Oral Diog / oral Med.11. 541-545 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 尾崎晴美: "Substance Pの免疫組織化学的検索を試みた顎関節症の2例" 日 口外誌. 44. 823-825 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 吉田博昭: "ヒト顎関節標本におけるサブスタンス・Pの発現について(免疫組織化学的研究)" 歯界展望. 92. 1153-1157 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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