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Epidemiological study and candidate gene analysis of cleft lip and /or plate in Japanese patients

Research Project

Project/Area Number 10671903
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKitasato University

Principal Investigator

YAMAZAKI Yasuharu  Kitasato Univ., School of Medicine, Assistant Professor, 医学部, 講師 (00210401)

Co-Investigator(Kenkyū-buntansha) AMAGASA Mituo  Tokyo Med. & Dent. Univ., School of Dentistry, Professor, 歯学部, 教授 (00014332)
OIDA Shinichiro  Turumi Univ., School of Dentistry, Associate Professor, 歯学部, 助教授 (10114745)
NAKAKITA Nobuaki  Kitasato Univ., School of Medicine, Associate Professor, 医学部, 助教授 (40180260)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordscleft lip and / or plate / multifactorial diseases / combined malformation
Research Abstract

1. Epidemiological study of 467 cleft lip and /or plate patients in Kitasato Univ. 25 years In the past: (1) Sex, (2) Age when operating, (3) Birthplace, (4) Multifactorial diseases, (5) Birth Order, (6) Lineage appearance rate & Brothers appearance rate, (7) Classification of Cleft (bilateral/unilateral cleft lip and palate, cleft hard and soft palate, cleft soft palate, submucous cleft palate), (8) Change at annuals of operation number.
Results; (1) Sex- male: female=249:217 (2) Age when operating- average: seven months a years old, (3) Birthplace- Kanagawa Pref, 78.4%, (4) Multifactorial diseases- 92cases 19.7%, (5) Birth Order- the first child: 191cases 40.9%, the second child: 203cases 43.5%, the third child: 67cases 14.3%, the fourth child: 5cases 1.1%, (6) Lineage appearance rate -16.5%, (7) bilateral/unilateral cleft lip and palate: 254cases 43.5%,, cleft hard and soft palate: 73cases 15.6%, cleft soft palate: 93cases 19.9%, submucous cleft palate: 10cases 10.1%, (8) Change at annuals of operation number-average during year: 20cases.
2. Investigation of multifactorial diseases appearance rate in each cleft and lineage appearance rate: (1) Multifactorial diseases-Total appearance rate: 94/467 20.1%, cleft lip and palate: 29/251 11.6%, cleft hard and soft palate: 28/55 50.9%, cleft soft palate: 24/92 26.1%, submucous cleft palate: 9/48 18.8%. (2) Lineage appearance rate-36/218 16.5%. High multifactorial diseases appearance rate (61/195 31.1%) was observed in isolated cleft palate.
3. Candidate gene analysis of cleft lip and /or plate in Japanese patients:
We are examining HLA class I (HLA-B) and class II alleles (HLA-DRB1 and DPB1) in Japanese patients with CL/P using high resolution DNA typing methods. At present, the result has not come out yet.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] M. Isobe: "The role of reconbinant human bone morphogenetic protein-2 in PLGA capsules at an extraskeletal site of the rat."Journal of Biomedical Materials Research. 45. 36-41 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N. Nakakita: "Augmentation Rhinoplasty by using L-shaped auricular cartilage Frame work with demol-fat grraft for cleft lip nose."Aesthetic Plastic Surgery. 23. 107-112 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Isobe: "Bone regeneration by the polymar caapsules containing recombinant human bone morphogenotic protein-2"Journal of Oral and Maxillofacial Surgery. 57. 695-698 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中北信昭: "三角弁法による片側不完全口唇裂初回手術後の患側上唇下垂について"日本形成外科学会会誌. 19. 71-79 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Goseki-Sone: "Expression of mRNA encoding tissue-ponspecific alkaline phosphatase in human dental tissues."Calcified Tissue International. 64. 160-162 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Watanabe: "Molecular diagnosis of hypophosphatasia with severe periodontitis"Journal of Periodotology. 70. 688-691 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 山崎安晴: "唇裂鼻の治療-臨床像と手術-(分担)"克誠堂(印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Goseki-Sone, T. Iimura, K. Takeda, A. Nifuji, Y. Ogata, M. Yanagishita, and S. Oida: "Expression of mRNA encoding tissue-nonspecific alkaline phosphstase in human dental tissues"Calcified tissue International. 64. 160-162 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masae Goseki-Sone, Hideo Orimo, Tadahiro Iimura, Hidetaka Miyazaki, Kimimitu, Oda, Hisanobu Shibata, Masaki Yanagisita, Yuzo Takagi, Hisahi Watanabe, Takasi Shimada, and Shinichiro Oida: "Expression of the mutant(1735T-del) tissuenonspecific alkaline phosphatase gene from hypophosphatasia patients"Journal of Bone and Mineral Research. 13. 1827-1834 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masatsugu Isobe, Yasuharu Yamazaki, Masahiro Mori, Kazuhiko Ishihara, Nobuo Nakabayashi, and Teruo Amagasa: "The role of recombinant human bone morphogenetic prote in-2 in PLGA capsules at an extraskeletal site of the rat"J Biomed. Mater. Res.. 45. 36-41 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mikio Ishiyama, Masato Mikami, Hitoyata Shimokawa, and Shinichiro Oida: "Amelogenin protein in tooth germs of the snake Elaphe quadrivirgata, immunohistichemistry, cloning and cDNA sequence"Arch. Histol. Cytol.. 61. 467-474 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hisahi Watanabe, Masae Goseki-Sone, Tadahiro Iimura, Shinichiro Oida, Hideo Orimo, and Isao Ishikawa: "Molecular diagnosis of hypophosphatasia with severe periodontitis"J Periodontol. 70. 688-691 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nobuaki Nakakita, Kouichirou Sezaki, Yasuharu Yamazaki, Eiju Uchinuma: "The cause of long lip deformity in unilateral incomplete cleft lip cases following triangular flap repair"J.Jpn.P.R.S.. 19. 71-79 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nobuaki Nakakita, Kouichirou Sezaki, Yasuharu Yamazaki, Eiju Uchinuma: "Augmentation rhinoplasty by using L-shaped auricular cartilage framework with dermal-fat graft for cleft lip Nose"Aesthetic Plastic Surgery. 23. 107-112 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masatsugu Isobe, Yasuharu Yamazaki, Masahiro Mori, and Teruo Amagasa: "Bone regeneration by the polymer capsules containing recombinant human bone morphogenetic protein-2"J. Oral. Maxillofac. Surg.. 57. 695-698 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masahiro Mori, Masatsugu Isobe, Yasuharu Yamazaki, Kuzuhiko Ishihara, and Nobuo Nakabayashi: "Restoration of segmental radial defects in rabbit bybiodegradable capsules containing recombinant human bone morphogenetic protein-2"J. Biomed. Mater. Res.. 50. 191-198 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Isobe: "The role of recombinant human bore morphogenetic protein-2 in PLGA capsules at an extraskeletal site of the rat."Journal of Biomedical Materials Research. 45. 36-41 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N. Nakakita: "Augmentation Rhinoplasty by using L-shaped auricular cartilage Frame word with dermal-fat graft for cleft lip nose."Aesthetic Plastic Surgery. 23. 107-112 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M. Isobe: "Bone regeneration by the polymer capsules containing recombinant human bone morphogenetic protein-2"Journal of Oral and Maxillotecil Surgery. 57. 695-698 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中北信昭: "三角弁法による片側不完全口唇裂初回手術後の患側上唇下垂について"日本形成外科学会会誌. 19. 71-79 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M. Goseki-Sone: "Expression of mRNA encoding tissue-nonspecific alkaline phosphatase in human dental tissues"Calcified Tissue International. 64. 160-162 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H. Watanabe: "Molecular diagnosis of hypophosphatasia with severe periodontics"Journal of Periodontology. 70. 688-691 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 山崎安晴: "唇裂鼻の治療-臨床像と手術-(分担)"克誠堂(印刷中). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中北信昭: "三角弁法による片側不完全口唇裂初回手術後の患側上唇下垂について" 日本形成外科学会会誌. 19(2)(印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nobuaki Nakakita: "Augmentation Rhinoplasty by using L-Shaped Auricular Cartilage Framework with Dermal-Fat Graft for Cleft Lip Nose" Aesthetic Plastic Surgery. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masatsugu Isobe: "The role of recombinant human bone morphogentic protein-2 in PLGA capsules at on extraskeletal site of the rat" J.Biomed.Mater.Res.45. 36-41 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masatsugu,Isobe: "Bone regeneration by the polymer capsules containing recombinant human bone morphogenetic protein-2" J.Oral Maxillofac.Surg.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masahiro Mori: "Restoration of segmental radial clefects in rabbit by bio degradable capsules containing recombinant human bone morphogentic protein-2" J.Biomed.Mater.Res. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shinichiro Oida: "Biological activities of bone extract containing TGF-6 superfamily protein." Journal of Hard Tissue Biology. 7(1). 27-34 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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