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Regeneration on peri-implant tissues by bone morphogenetic protein

Research Project

Project/Area Number 10671964
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ODA Shigeru  Tokyo Med. & Dent. Univ., Fac of Dent. Lecturer, 歯学部, 講師 (70160869)

Co-Investigator(Kenkyū-buntansha) KINOSHITA Atsuhiro  Tokyo Med. & Dent. Univ., Fac of Dent. Instructor, 歯学部, 助手 (10242207)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsBone Morphogenetic Protein / BMP / Implant / Dog / Osseointegration
Research Abstract

The objective of this study was to investigate regeneration on peri-implant tissues (bone, connective tissue and epithelium) following installation of fixtures with application of recombinant human bone morphogenetic protein-2 (rhBMP-2).
All mandibular premolars of 6 beagle dogs were extracted. After 3 month of healing, apical 5 mm of 10 mm fixtures (Bronemark System【encircledR】, length : 10 mm, diameter : 3.75 mm) were installed in bilateral edentulous bone ridges. RhBMP-2(0.4 mg/ml) with polylactic acid polyglycolic acid copolymer / gelatin sponge (PGS) was applied to cover the coronal half of the fixture in the experimental side. In the opposite side of the mandible, the coronal half of the fixture was covered with PGS alone. RhBMP-2 and PGS were supplied by Yamanouchi Pharmaceutical Co., Ltd.. Three months after installation, the dog was sacrificed. Immediately, the implant regions were dissected and fixed. Undecalcified sections were prepared. Radiographs were taken every two weeks.
Postoperative swelling was observed in the experimental group. Radiographs after 3 months revealed that a large amount of bony tissue regenerated in the experimental group, while the bone height in the control group was almost the same as compared to pre-surgery.
In the experimental group, bone regeneration was significantly greater than in the control group (p<0.01, paired t-test). Furthermore, the epithelial downgrowth in the experimental group was inhibited significantly as compared with the control group (p<0.01, paired t-test).
The results of this experiment suggest that recombinant human bone morphogenetic protein-2 (rhBMP-2) may enhance tissue regeneration on peri-implant tissue around the fixture.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Higuchi T et al.: "Bone Regeneration by Reecombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)in Rat Mandibular Defects"Journal of Periodontology. Vol.70. 1026-1031 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小田茂: "歯周治療における日常臨床のヒント -注意すべきポイント-<その1>"日本歯科医師会雑誌. 第52巻. 35-40 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小田茂: "歯周治療における日常臨床のヒント -注意すべきポイント-<その2>"日本歯科医師会雑誌. 第52巻. 29-33 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishikawa I et al.: "Evaluation of the Er : YAG Laser Scaling of Subgingival Calculus In Vitro in Comparison with the Ultrasonic Scaling"Proceedings of the 6th International Congress on Lasers in Dentistry. 216-217 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 三浦真子他: "Er : YAGレーザーによる歯肉縁下歯石のスケーリング後の根面の性状について"日本レーザー歯学誌. 第9巻. 60-67 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石川烈他: "現在の歯周治療の潮流から : 歯周ポケットのとらえ方と超音波スケーラー"歯科衛生士. 第22巻. 17-28 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 諸留よう子他: "別冊ザ・クインテッセンスYEAR BOOK1998歯科年鑑 各種GROWTH FACTORの歯周治療への応用"クインテッセンス出版. 377 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小田茂他: "別冊ザ・クインテッセンス臨床家のための矯正YEAR BOOK98骨誘導システムの開発Recombinant Human Bone Morphogenetic Protein-2の歯周組織再生療法への応用"クインテッセンス出版. 291 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Higuchi T et al.: "Bone regeneration by Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) in Rat Mandibular Defects."Journal of Periodontology. Vol. 70, No. 9. 1026-1031 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishikawa I et al.: "Evaluation of the Er : YAG Laser Scaling of Subgingival Calculus In Vitro in Comparison with the Ultrasonic Scaling."Proceedings of the 6th International Congress on Lasers in Dentistry. 216-217 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miura M et al.: "Observation of the Root Surface after Subgingival Calculus Scaling by Er : YAG Laser Irradiation : Comparison with Ultrasonic Scaling."Journal of Japanese Society for Laser Dentistry. Vol. 9, No. 1. 60-67 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oda S et al.: "Bone Regeneration Around Implants by rhBMP-2."Proceedings of the 4th World Congress for Oral Implantology. 167 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kikuchi S et al.: "Periodontal Regeneration with EMDOGAIN ; A Preliminary Study in Dogs."Program and Abstracts of Papers Japanese Association for Dental Research 46th Annual Meeting. 114 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oda S et al.: "Development of Periodontal Regenerative Therapy by Bone Morphogenetic Protein (BMP) Periodontal Regeneration by Application of Recombinant Human Bone Morphogenetic Protein-2."The Quintessence Orthodontics Year Book 98, Quintessence Publishing Co., Ltd... 10-15 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Morotome Y et al.: "The Possible Application of Growth Factors to Periodontal Regeneration Therapy."The Quintessence Orthodontics Year Book 98, Quintessence Publishing Co., Ltd... 11-18 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Higuchi T et al.: "Bone Regeneration by Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) in Rat Mandibular Defects"Journal of Periodontology. 70・9. 1026-1031 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小田 茂: "歯周治療における日常臨床のヒント-注意すべきポイント-<その1>"日本歯科医師会雑誌. 52・2. 35-40 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小田 茂: "歯周治療における日常臨床のヒント-注意すべきポイント-<その2>"日本歯科医師会雑誌. 52・3. 29-33 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ishikawa I et al.: "Evaluation of the Er: YAG Laser Scaling of Subgingival Calculus In Vitro in Comparison with the Ultrasonic Scaling"Proceedings of the 6th International Congress on Lasers in Dentistry. 216-217 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 三浦真子 他: "Er:YAG レーザーによる歯肉縁下歯石のスケーリング後の根面の性状について"日本レーザー歯学誌. 9・1. 60-67 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石川 烈 他: "現在の歯周治療の潮流から:歯周ポケットのとらえ方と超音波スケーラー"歯科衛生士. 22・8. 17-28 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 諸留 よう子 他: "別冊ザ・クインテッセンス YEAR BOOK1998 歯科年鑑各種 GROWTH FACTOR の歯周治療への応用"クインテッセンス出版. 377 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小田 茂 他: "別冊ザ・クインテッセンス臨床家のための矯正 YEAR BOOK 98 骨誘導システムの開発, Recombinant Human Bone Morphogenetic Protein-2 の歯周組織再生療法への応用"クインテッセンス出版. 291 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Higuchi T et al.: "Bone Regeneration by Recombinant Human Bone Morphogenetic Protein-2(rhBMP-2)in Rat Mandibular Defects.." Journal of Periodontology. 70(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 三浦真子 他.: "Er : YAGレーザーによる歯肉縁下歯石のスケーリング後の根面の性状について" 日本レーザー歯学会誌. 9・1. 60-67 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Oda S et al.: "Bone regeneration around implants by rhBMP-2.-apilot study in dog.-" Proceedings of 4th World Congress for Oral Implantology. 4. 167 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 諸留ようこ 他: "別冊ザ・クインテッセンス YEAR BOOK 98 各種GROWTH FACTOR の歯周治療への応用" クインテッセンス出版, 337 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小田 茂 他: "別冊ザ・クインテッセンス 臨床家のための矯正YEAR BOOK 98骨誘導システムの開発 rhBMP-2の歯周組織再生療法への応用" クインテッセンス出版, 291 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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