| Project/Area Number |
10671977
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
TAKASUGI Mitsuo Hokkaido Univ., Grad. School of Environ. Earth Sci., Pro., 大学院・地球環境科学研究科, 教授 (70000833)
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| Co-Investigator(Kenkyū-buntansha) |
ANETAI Masaki Hokkaido Institute of Public Health, 薬理毒性部, 薬理資源課長(研究担当)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | stress compound / medicinal plant / crude drug / processing / Umbelliferae / screening / Araceae / Araliaceae / アルカロイド / タデ科 / 抗菌性 / ニガキ科 |
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| Research Abstract |
Stress compounds induced in plant tissues of medicinal plants during the processing of raw material were shown as potential constituents of crude drugs. Since stress compounds show biological activities, evaluation of the compounds in crude drugs is very important . Bioassay-directed fractionation of plant extracts from the stressed tissues of medicinal or related plants resulted in the isolation of stress compounds required for authentic markers of crude drug analysis .
Umbelliferae: Glehnia littoralis, Saposhinikovia divaricata, Angelica acutiloba, and A. acutiloba var. sugiyamae gave psoralen and related furanocoumarins; Cnidium officinale gave senkyunolide B. Araceae: Amorphophalus konjac gave two pyrrolidine alkaloids; Colocasia esculenta gave 1 pyrrolidine alkaloid and 3 piperidine alkaloids; Pinellia ternata gave 1 piperidine alkaloid. Paeonia lactiflora gave hederagenin. Acanthopanax divaricatum gave scoparone and 2 CィイD217ィエD2butenolides. Rheum palmatum gave 3 anthraquinones and 1 bianthrone as stress compounds.
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