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Characterization of Hepatoprotective Compounds from Chinese Medicinal Herbs with Anti-alcoholic Activity

Research Project

Project/Area Number 10672010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

YOSHIKAWA Masayuki  Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (90116129)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Toshiyuki  Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences, Research Assistant, 薬学部, 助手 (40278445)
MATSUDA Hisahi  Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (40288593)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsanti-alcoholic principle / Chinese medical herb / hepatoprotective effect / ethanol intoxication / Zedoary / Bupleuri Radix / Notoginseng / gastroprotective effect / 解酒生薬 / 月桂樹 / costunolide / dehydricostus lactone / アルコール吸収抑制活性 / α-methyl-γ-lactone / 胃粘膜保護作用 / 肝保護作用
Research Abstract

Many Chinese medicinal herb have been known to have preventive and therapeutic effects for ethanol intoxication, but their active components have not been identified so far. In the course of our screening to find anti-alcoholic active principles contained in Chinese medicinal herbs, the methanolic extracts of several herbs were found to show potent protective activity on liver injury induced by D-galactosamine and lipopolysaccharide in rats. By monitoring the hepatoprotective effects, we have characterized new active principles ; that is, 1) sesquiterpenes (curcarabranols) from Zedoary (Zedoariae rhizoma), 2) tritepene glycosides bupleurosides, scorzonerosides) from Bupleuri Radix (Bupleurum scorzonerifolium), 3) dammarane-type saponins (notoginsenosides, quinquenosides) from Notoginseng (Panax dammarane-type saponins (notoginsenosides, quinquenosides) from Notoginseng (Panax notoginseng) and American ginseng (Panax quinquefolium), 4) coumarins (hyuganins) from angelica funcijuga, 5) diarylheptanoids (betulaplatosides) from Betula platyphylla, 6) oleanene-type saponins (escins, assamsaponins) from Aesculus hippocastanum and Thea sinensis. These compounds with hepatoprotective activity exhibited NO production inhibitory activity in lipopolysaccharide-activated macrophages, gastroprotective superoxide scavenging, and antioxidative activities.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Masayuki Yoshikawa: "Inhibitory Effect and Action Mechanism of Sesquiterpenes form Zedoariae Rhizoma on D-Galactosamine/Lipopolysaccharide-Induced Liver Injury"Bioorganic & Medicinal Chemistry Letters. 8. 339-344 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa: "Bioactive Saponins and Glycosides. XI. Structures of New Dammarane-Type Triterpene Oligoglycosides, Quinquenosides I, II, III, IV, and V, from American Ginseng, the Roots of Panax quinquefolium L"Chemical & Pharmaceutical Bulletin. 46. 647-654 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa: "Absolute Stereostructures of Carabrane-Type Sesquiterpenes, Curcumenone, 4S-Dihydrocurcumenone, and Curcarabranols A and B : Vasorelaxant Activity of Zedoary Sequiterpenes"Chemical & Pharmaceutical Bulletin. 46. 1186-1188 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa: "Hepatoprotective, Superoxide Scavenging, and Antioxidative Activities of Aromatic Constituents from the Bark of Betula platyphylla var. japonica"Bioorganic & Medicinal Chemistry Letters. 8. 2939-2944 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa: "Effects of Sesquiterpenes and Triterpenes from the Rhoizome of Alisma orientale on Nitric Oxide Production in Lipopolysaccharide-Activated Macrophages : Absolute Stereostructures of Alismaketones-B 23-Acetate and -C23-Acetate"Bioorganic & Medicinal Chemistry Letters. 9. 3081-3086 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa: "Preventive Effects of Sesquiterpenes from Bay Leaf on Blood Ethanol Elevation in Ethanol-Loaded Rat : Structure Requirement and Suppression of Gastric Emptying"Bioorganic & Medicinal Chemistry Letters. 9. 2647-2652 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hisashi Matsuda, Kiyofumi Ninomiya, Toshio Morikawa, and Masayuki Yoshikawa: "Inhibitory Effect and Action Mechanism of Sesquiterpenes from edoariae Rhizoma on D-Galactosamine/Lipopolysaccharide-Induced Liver Injury"Bioorg. Med. Chem. Lett.. 8. 339-344 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa, Toshiyuki Murakami, Kenichi Yashiro, Johji Yamahara, Hisahi Matsuda, Reiko Saijoh and Osamu Tanaka: "Bioactive Saponins and Glycosides. "XI". Structures of Nes Dammarane-Type Triterpene Oligoglycosides, Quinquenosides "I", "II","III","IV"and "V" from American Ginseng, the Roots of Panax quinquefolium L."Chem.Pharm. Bull.. 46. 647-654 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa, Toshiyuki Murakami, Tosho Morikawa, and Hisashi Matsuda: "Absolute Stereostructures of Carabrane-Type Sesquiterpenes, Curcumenone, 4S-Dihydrocucumenone, and Curcarabranols A and B : Vasorelaxant Activity of Zedoary Sesquiterpenes"Chem. Pharm. Bull.. 46. 1186-1188 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hisashi Matsuda, Atsushi Ishikado, Norihida, Kiyofumi Ninomiya,Hiromi Fujiwara, Yasunopbu Kobayashi and Masayuki Yoshikawa: "Hepatoprotective, Superoxide Scavenging, and Antioxidative Activities of Aromatic Constituents from the Bark of Betula platyphylla var, japonica"Bioorg. Med. Chem.Lett.. 8. 2939-2944 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hisashi Matsuda, Toshiyuki Murakami, Tadashi Kageura, Kiyofumi Ninomiya, Iwao Toguchida, Norihisa Nishida and Masayuki Yoshikawa: "Hepatoprotective and Nitric Oxide Production Inhibitory Activities of Coumarin and Polyacetylene Constituents from the Roots of Angelica furcijuga"Bioorg. Med. Chem. Lett.. 8. 2191-2196 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hisashi Matsuda, Yuhao Li, Toshiyuki Murakami, Johji Yamahara and Masayuki Yoshikawa: "Protective Effects of Oleanolic Acid Oligoglycosides on Ethanol-or Indomethacine-Induced Gastric Mucosal Lesions in Rats."Life Sci. 63. PL245-250 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa, Toshio Morikawa, Toshiyuki Murakami, Iwao Toguchida, Shoichi Harima and Hisashi Matsuda: "Medicinal Flowers. "I".Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B and C from the Flowers of Chrysanthemum indicum L."Chem.Pharm. Bull.. 47. 240-245 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hisashi Matsuda, Tadashi Kageura, Iwao Toguchida, Toshiyuki Murakami, Akinobu Kishi and Masayuki Yoshikawa: "Effects of Sesquiterpenes and Triterpenes from the Rhizome of Alsma orientale of Nitric Oxide Production in Lipopolysaccharide-Activated Macrophages : absolute Stereostructures of Alismaketones-B 23 Acetate and -C23-Acetate."Bioorg. Med. Chem. Lett.. 9. 3081-3086 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hisashi Matsuda, Hitoshi Shimoda, Toshiaki Uemura and Masayuki Yoshikawa: "Preventive Effect of Sesquiterpenes from Bay leaf on Blood Ethanol Elevation in Ethanol-Loaded Rat : Structure Requirement and Suppression of Gastric Emptying."Bioorg. Med. Chem. Leett.. 9. 2647-2652 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toshiyuki Murakami, Juko Nakamura, Hisashi Matsuda and Masayuki Yoshikawa: "Bioactive Saponins and Glycosides."XV" Saponin Constituents with Gastoprotective Effect from the Seeds of Tea Plant, Camellia sinensis L. var assamica PIERRE, Cultivated in Sri Lanka : Structures of Assamsaponins A,B,C,D and E"Chem. Pharm. Bull.. 47. 1759-1764 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hisashi Matsuda, Yuhao Li and Masayuki Yoshikawa: "Gastroprotections of Escins Ia, Ib, IIa and IIb on Ethanol-Induced Gastric Mucosal Lesions in Rats."Eur.J.Pharmacol.. 373. 63-70 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masayuki Yoshikawa: "Effects of Sesquiterpenes and Triterpenes from the Rhoizome of Alisma orientale on Nitric Oxide Production in Lipopolysaccharide-Activated Macrophages:Absolute Stereostructures of Alismaketones-B 23-Acetate and-C23-Acetate"Bioorganic&Medicinal Chemistry Letters. 9. 3081-3086 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masayuki Yoshikawa: "Preventive Effects of Sesquiterpenes from Bay Leaf on Blood Ethanol Elevation in Ethanol-Loaded Rat:Structure Requirement and Suppression of Gastric Emptying"Bioorganic&Medicinal Chemistry Letters. 9. 2647-2652 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masayuki Yoshikawa: "Medicinal Flowers.I.Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes,KikkanolsA,B,andC,from the Flowers of Chrysanthemum indicumL."Chemical&Pharmaceutical Bulletin. 47・3. 340-345 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masayuki Yoshikawa: "Bioactive Saponins and Glycosides.XV.Saponin Constituents with Gastroprotective Effect from the Seeds of Tea Plant,Camellia sinensisL.var.assamica Pierre,Cultivated in Sri Lanka:Structures of AssamsaponinsA,B,C,D,andE."Chemical&Pharmaceutical Bulletin. 47・12. 1759-1764 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masayuki Yoshikawa: "Inhibitory Effect and Action Mechanism of Sesquiterpenes from Zedoariae Rhizoma on D-Galactosamine/Lipopolysaccharide-Induced Liver Injury" Bioorganic & Medicinal Chemistry Letters. 8. 339-344 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masayuki Yoshikawa: "Bioactive Saponins and Glycosides. XI.Structres of New Dammane-Type Triterpene Oligoglycosides,Quinquenosides I,II,IV,and V,from American Ginseng,the Roots of Panax quinquefolium L." Chemical & Pharmaceutical Bulletin. 46・4. 647-654 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masayuki Yoshikawa: "Absolute Stereostructures of Carabrane-Type Sesquiterpenes,Curcumenone,4S-Dihydrocumenone,and Curcarabranols A and B : Vasorelaxant Activity of Zedoary Sesquiterpenes" Chemical & Pharmaceutical Bulletin. 46・7. 1186-1188 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masayuki Yoshikawa: "Hepatoprotective,Superoxide Scavenging,and Antioxidative Activities of Aromaatic Constituents from the Bark of Betula platypylla var.japonica" Bioorganic & Medicinal Chemistry Letters. 8. 2939-2944 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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