| Project/Area Number |
10672010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
YOSHIKAWA Masayuki Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (90116129)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Toshiyuki Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences, Research Assistant, 薬学部, 助手 (40278445)
MATSUDA Hisahi Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (40288593)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | anti-alcoholic principle / Chinese medical herb / hepatoprotective effect / ethanol intoxication / Zedoary / Bupleuri Radix / Notoginseng / gastroprotective effect / 解酒生薬 / 月桂樹 / costunolide / dehydricostus lactone / アルコール吸収抑制活性 / α-methyl-γ-lactone / 胃粘膜保護作用 / 肝保護作用 |
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| Research Abstract |
Many Chinese medicinal herb have been known to have preventive and therapeutic effects for ethanol intoxication, but their active components have not been identified so far. In the course of our screening to find anti-alcoholic active principles contained in Chinese medicinal herbs, the methanolic extracts of several herbs were found to show potent protective activity on liver injury induced by D-galactosamine and lipopolysaccharide in rats. By monitoring the hepatoprotective effects, we have characterized new active principles ; that is, 1) sesquiterpenes (curcarabranols) from Zedoary (Zedoariae rhizoma), 2) tritepene glycosides bupleurosides, scorzonerosides) from Bupleuri Radix (Bupleurum scorzonerifolium), 3) dammarane-type saponins (notoginsenosides, quinquenosides) from Notoginseng (Panax dammarane-type saponins (notoginsenosides, quinquenosides) from Notoginseng (Panax notoginseng) and American ginseng (Panax quinquefolium), 4) coumarins (hyuganins) from angelica funcijuga, 5) diarylheptanoids (betulaplatosides) from Betula platyphylla, 6) oleanene-type saponins (escins, assamsaponins) from Aesculus hippocastanum and Thea sinensis. These compounds with hepatoprotective activity exhibited NO production inhibitory activity in lipopolysaccharide-activated macrophages, gastroprotective superoxide scavenging, and antioxidative activities.
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