| Project/Area Number |
10672078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
SUGIMOTO Yumi Kobe Pharmaceutical University, Pharmaceutical Sciences, lecturer, 薬学部, 講師 (50187671)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Serotonin receptor / Nitric oxide / Feeding behavior / Hyperphagic animal models |
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| Research Abstract |
Serotonin (5-hydroxytryptamine, 5-HT) is known as a neurotransmitter which suppresses food intake. 5-HT receptors are divided into many subtypes. 5-Carboxamidotryptamine (5-CT) is a peripherally acting 5-HT receptor agonist with a high affinity with 5-HTィイD27ィエD2 receptors. I found that 5-CT inhibits hyperhagia in food-deprived 2-deoxy-D-glucose-treated rats. It suggests that 5-HTィイD27ィエD2 receptors are involved in regulation of food intake. It has been reported that nitric oxide(NO) is also participates in food intake. I found that the NO synthase inhibitor suppressed 2-deoxy-D-glucose-induced hyperphagia in rats. It indicates that NO plays a significant role in regulation of food intake. The effects of the neuronal NO synthase inhibitor 7-nitroindazole on 8-OH-DPAT-induced hyperphagia, which is mediated by the 5-HTィイD21AィエD2 autoreceptor, were investigated in rats. 7-Nitroindazole suppressed 8-OH-DPAT-elicited increases in food intake. Although 8-OH-DPAT decreases 5-HT synthesis, 7-nitroindazole did not reverse the 8-OH-DPAT-elicited decrease in 5-HT synthesis. Therefore, these results indicate that NO formed in the brain is involved in 8-OH-DPAT-induced hyperphagia and that the hypophagic effects of 7-nitroindazole are not dependent on 5-HT synthesis.
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