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Ethical issues in human gene analysis

Research Project

Project/Area Number 10672135
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionKinki University

Principal Investigator

TAKEBE Hiraku  Kinki University, Atomic Energy Research Institute, Professor, 原子力研究所, 教授 (10028318)

Co-Investigator(Kenkyū-buntansha) FURUYAMA Junichi  Hyogo College of Medicine, Department of Genetics, Professor, 医学部, 教授 (30068431)
KAKEE Naoko  Advancd Research Center for Human Sciences, Waseda University, Instructor, 人間総合研究センター, 助手 (70298206)
KUROKI Yoshikazu  Kanagawa Children's Medical Center, Department of Medical Genetics, Medical Director, 所長
巽 純子  京都大学, 医学研究科, 助手 (80128222)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1999: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordshuman genome / HUGO / genetics / ethics / 遺伝子検査 / 遺伝子治療 / 倫理 / 家系
Research Abstract

Objectives : Human genome analysis is expected to be completed within a few years. Ethical considerations are indispensable in analyzing human DNA and in informing the outcome of the genome analysis to the persons tested. In Japan, education of human genetics has been scarce in medical schools, and most of the practicing doctors as well as researchers in medical sciences have little knowledge of human genetics. This study intends to establish the minimum needed knowledge of human genetics for medical doctors and co-medical staff members, to meet the genome-based medical practice.
Results and Discussion : Two meetings, one each in fiscal 1998 and 1999, were held to discuss the topics related to the projects. In 1998-1999, emphasis was put on the role of mass-media for the public acceptance of the human genome research. In 1999-2000, we discussed the proposed guideline for the human gene diagnosis and analysis by the Ministry of Health and Welfare. Major outcomes and conclusions of the discussion are the followings.
1. Japan and western countries are considerably different in understanding human heredity, and we need our own guideline in addition to those prepared by WHO, HUGO and other international organizations.
2. We should promote education of human genetics in all levels, particularly in medical education.
3. For the immediate needs, this group will translate the excellent guidebook "Human Genetics" by British Medical Association, and will continue to write its Japanese version for Japanese medical community.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] 武部 啓: "遺伝子医療の倫理"脳の科学. 21. 1235-1240 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 武部 啓: "ゲノムと倫理 : ヒトゲノム解析に伴う倫理的問題"現代医療. 32. 299-302 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 黒木 良和: "遺伝カウンセリング"臨床医. 25. 53-57 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanaka Y, Masuno M, Iwamoto H, Kuroki Y et al.: "Noonan Syndrome and Cavernous Hemangioma of the Brain"American Journal of Medical Genetics. 82. 212-214 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 恒松由記子、掛江直子: "家族性腫瘍における遺伝子診断の研究とこれを応用した診療に関するガイドライン(案)-作成の経緯と主旨"遺伝子医学. 3. 132-136 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 妹尾純子、王置(橋本)知子、古山順一、他: "妊婦血清マーカー検査の羊水診断に与える影響-羊水穿刺実施時期を中心に-"臨床遺伝研究. 20. 103-108 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yagi T, Katsuya A, Koyano A and Takebe H: "Sensitivity of group F xeroderma pigmentosum cells to UV and mitomycin C relative to levels of XPF and ERCC1 overexpression"Mutagenesis. 13(6). 595-599 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuda T, Kawanishi M, Yagi T, Matsui S and Takebe H: "Specific tandem GG to TT base substitutions induced by acetaldehyde are due to intra-strand crosslinks between adjacent guanine bases"Nucleic Acids Research. 26(7). 1769-1774 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yagi T, Mohri-Nakanishi K, Matsuda T, Yamagishi N, Miyakoshi J, Takebe H: "Reduced UV-induced mutations in human osteosarcoma cells stably expressing transfected wild-type p53cDNA"Cancer Letters. 123. 71-76 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masuno M, Imaizumi K, Ishii T, Kuroki Y, Baba N, Tanaka Y: "Pilomatrixomas in Rubinstein-Taybi Syndrome"American Journal of Medical Genetics. 77. 81-82 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Imaizumi K, Ishii T, Matsuno M and Kuroki Y: "Association of holoprosencephaly, ectrodactyly, cleft lip/cleft palate and hypertelorism : a possible third case"Clinical Dysmorphology. 7. 213-216 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ito R, Tamura K, Ashida H, Nishiwaki M, Nishioka A, Yamamoto Y, Furuyama J and Utsunomiya J: "Usefulness of K-ras gene mutation at codon 12 in bile for diagnosing biliary strictures"International Journal of Oncology. 12. 1019-1023 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanaka Y, Masuno M, Iwamoto H, Aida N, Ijiri R, Yamanaka S, Imaizumi K, and Kuroki Y: "Noonan Syndrome and Cavernous Hemangioma of the Brain"American Journal of Medical Genetics. 82. 212-214 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanaka K, Sugita H, Uehara M, Sato H, Hashimoto-Tamaoki T and Furuyama J: "Association between mast cell chymase genotype and atopic eczema : comparison between patients with atopic exzema alone and those with atopic eczema and atopic respiratory disease"Clinical and Experimental Allergy. 29. 800-803 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Li G, Tamura K, Yamamoto Y, Sashio H, Utsunomiya J, Yamamura T, Shinoyama T and Furuyama J: "Molecular and Clinical Study of Familial Adenomatous Polyposis for Genetic Testing and Management"J. Exp. Clin. Cancer Res. 18. 519-529 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 武部啓: "ヒトゲノム解析に伴う倫理的問題"現代医療. 32-1. 299-302 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 武部啓: "遺伝子医療の倫理"脳の科学. 21. 1235-1240 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] A.Nakayama,M.Kawanishi,H.Takebe et al.: "Molecular analysis of mutations induced by a benzene metabolite,p-benzoquinone."Mutation Research. 444. 123-131 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 黒木良和: "遺伝カウンセリング"臨床医. 25. 1231-1235 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 恒松由記子、掛江直子: "「家族性腫瘍における遺伝子診断の研究とこれを応用した診療」ガイドライン"遺伝子医学. 3-2. 132-136 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 古山順一 他: "染色体分析はどこまで進んだか"臨床婦人科産科. 53. 161-166 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 田村和朗、古山順一: "消化器科領域-大腸家族性腫瘍"中山書店. 349 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takebe,H.他3名: "Sensitivity of group F xeroderma pigmentosum cells to UV and mitomycin C relative to levels of XPC and ERCCl" Mutagensis. 13,6. 595-599 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takebe,H.他5名: "Mutagenic specificity of a derivative of 3-nitrobenz-anthrone in the supF shuttle vector plasmid." Chemical Research in Toxicology. 11,12. 1468-1473 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takebe,H.他4名: "suppression of high-density magnetic field-induced mutations by wild-type p53 expression in human cells" Biochemical and Biophysical Res,Comm.243,2. 579-584 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 武部 啓: "癌と遺伝" 老化と疾患. 11・8. 36-42 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 武部 啓: "北京での国際遺伝学会議と遺伝倫理の討議" 日中医学. 13・4. 13-15 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 武部 啓: "クローン羊が投げかけたもの" 創造の世界. 110(印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 武部 啓: "専門家集団の思考と行動(岩波謌産 科学/技術と人間2)" 岩波書店, 253(4) (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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