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Molecular Analysis of Glucose-6-phosphate dehydrogenase variants in southern Mongoloids

Research Project

Project/Area Number 10672140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionOkinaka Memorial Institute for Medical Research

Principal Investigator

HIRONO Akira  Okinaka memorial institute for medical research, Researcher, 研究員 (90181221)

Co-Investigator(Kenkyū-buntansha) MIWA Shiro  Okinaka memorial institute for medical research, Director, 所長 (40034954)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
KeywordsGlucose-6-phosphate dehydrogenase deficiency / G6PD variant / Southern Mongoloids / Molecular analysis / G6PD Viangchan / 溶血性貧血
Research Abstract

We have performed molecular analyses of G6PD deficiency cases found in Laos, Myanmar, Thailand, Indonesia and Japan.
1. All of 8 Laotian cases proved to have G6PD Viangchan.
2. In Myanmar and Thailand, 15 cases (11 Burmese, 3 Mon and 1 Shan) were found to have G6PD Mahidol, and one Burmese proved to have G6PD Union.
3. Of 6 G6PD-deficient subjects of Thai origin, 3 were associated with G6PD Viangchan, one with G6PD Mahidol and one with G6PD Vanua Lava. The other subject was a compound heterozygote for G6PD Union and G6PD Canton.
4. Of 6 subjects of Filipino origin, 5 had G6PD Viangchan, and the other two had G6PD Coimbra and G6PD Chatham, respectively.
5. In Halmahera island and Bulu island in Indonesia, we found 8 G6PD Vanua Lava cases and one G6PD Coimbra case. Two other Indonesian cases from Jawa island proved to have G6PD Chatham.
6. Of 11 subjects of Chinese origin, we identified G6PD Kaiping in 5 cases, G6PD Canton in 3 cases, G6PD Gaohe in one case and G6PD Mahidol-like in another case. The 11th subject was found to have a novel mutation 1291 G→A causing a unique class-2 variant G6PD Surabaya.
In summary, the southern Mongoloids may be classified into three groups in terms of G6PD mutations : Asian continent group (Chinese, Laotians, Thais and Burmese), Asian island group (Filipinos and some Indonesians), and Melanesian group (Melanesians and some Indonesians). Each group may be characterized by the typical G6PD mutations : G6PDs Canton, Kaiping and Mahidol ; G6PD Viangchan ; and G6PDs Union and Vanua Lava ; respectively.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Hirono, A et al.: "An improved single-step screening method for glucose-6-phosphate dehydrogenase deficiency"Japan J Trop Med Hyg. 26. 1-4 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyazono, Y et al.: "Erythrocyte enzyme activities in cord blood of extremely low-brirth-weight infants"Am J Hematol. 62. 88-92 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, A et al.: "Homolytic crisis after excessive ingestion of fava beans in a male infant with G6PD canton"Int J Hematol. 70. 233-235 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hirono, A., Fujii, H. & Miwa, S.: "An improved single-step screening method for glucose-6-phosphate dehydrogenase deficiency"Jpn J Trop Med Hyg. 26. 1-4 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyazono, Y., Hirono, A., Miyamoto, Y. & Miwa, S.: "Erythrocyte enzyme activities in cord blood of extremely low-birth-weight infants"Am J Hematol. 62. 88-92 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shibuya, A., Hirono, A., Ishii, S., Fujii, H., Miwa, S.: "Hemolytic crisis after excessive ingestion of fava beans in a male infant with G6PD Canton"Int J Hematol. 70. 233-235 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hirano A.et al.: "An improved single-step screening method for glucose-6-phosphate dehydrogenase deficiency"Japan J Trop Med Hyg. 26. 1-4 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Miyazono Y.et al.: "Erythrocyte enzyme activities in cord blood of extremely low-birth-weight infants"Am J Hematol. 62. 88-92 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shibuya A.et al.: "Hemolytic crisis after excessive ingestion of fava beans in a male infant with G6PD Canton"Int J Hematol. 70. 233-235 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Akira Hirono: "An improved single-step screening method for glucose-6-phosphate dehydrogenase deficiency" Japanese Journal of Tropical Medicine and Hygiene. 26(1). 1-4 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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