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The Relationship between Serum Glufosinate Concentration and Severity of Poisoning Caused by the Ingestion of a Herbicide Containing Glufosin

Research Project

Project/Area Number 10672144
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 応用薬理学・医療系薬学
Research InstitutionUniversity of Tsukuba

Principal Investigator

KOYAMA Kanji  Institute of Clinical Medicine, University of Tsukuba Assistant Professor, 臨床医学系, 講師 (70205532)

Co-Investigator(Kenkyū-buntansha) GOTO Katsutoshi  Institute of Basic Medicine Sciences, University of Tsukuba Professor, 基礎医学系, 教授 (30012660)
KOHDA Yukinao  Institute of Clinical Medicine, University of Tsukuba Professor, 臨床医学系, 教授 (40143482)
AKUZAWA Hisashi  Forensic Science Laboratory, Gunma Prefecture Police Headquaters Chief Resercher, 科学捜査研究所, 主任研究員
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsglofosinate / poisoning / coma / seizure / apnea / herbicide / agricultural chemical
Research Abstract

Acute oral poisoning with an berbicide BASTA^<【○!R】> causes consciousness disturbances, convulsions, and apnea after 6-40 hours of ingestion. Because, the patients look non-severe before the onset of these signs, the respiratory management might be late for sever patients. On the other hand, unnecessary intensive treatments such as hemopurifications are sometimes conducted for non-sever patients. For conducting a suitable management for this poisoning, by estimating the severity of this poisoning correctly before the onset of severe signs, we studied serum glufosinate concentration ([GLF]s)and amount ingested(AI)in relation to the severity of the patients.
[Method] Ninety-nine cases of BASTA^<【○!R】> ingestion were studied. Fifty-one cases that produced at least one of the following 3 sings : coma, generalized convulsions, and apnea, were defined as severe. Forty-eight cases that produced none of these sings were defined as non-severe. In each case, [GLF]s on admission was measured and AI was estimated. [GLF]s was plotted semi-logarythmically related to the hours after ingestion.
[Results][GLF]s of sever cases located higher than those of non-sever cases. All cases aboye the line connecting 210 ppm at 2 hours and 15 ppm at 8 houres were severe. On the contrary, all cases under the line connecting 80 ppm at 2 hours and 5 ppm at 8 hours were non-severe. Between these 2 lines, severe and non-severe cases existed half-and-half. The AI in severe cases were higher than those in non-severe cases(p<0.0001). However, sever cases and non-severe cases could not be discriminated clearly based on AI, because AI in both groups were widely distributed, overlapping with each other. [Conclusion][GLF]s on admission, which can be measured in about 3 hours by HPLC, is a valuable tool in predicting the severity of BASTA^<【○!R】> poisoning. (284 words)

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 小山完二、幸田幸直、阿久沢尚士 他: "グルホシネートの薬物動態-ウサギを用いた基礎的検討"日本救急医学会雑誌. 9. 556-557 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 小山完二: "グルホシネートを主成分とする除草剤による中毒"医学のあゆみ. 185. 192-193 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hirose Y, Kobayashi M, Koyama K etal.: "A Toxicokinetic Analysis in a Patient with Acute Glufusinate Poisoning"Hum.Exp.Toxicol.. 18. 305-308 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takahashi H, Toyat.Hatsumiya N, Kayama K: "A Case of Transient Diabetes Iusipidus Associated with Poisoning by a Herbicide Containing Glufosinate"Clinical Toxicology.. 38. 153-156 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 小山完二: "農薬中毒の診断基準、病型分類、重症度"内科. 85. 1625-1628 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 小山完二: "グルホシネート(バスタ液剤)"救急医学. 25. 141-143 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 小山完二: "今日の治療指針,多賀須幸男、尾形悦郎編"医学書院. 3 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Koyama K: "Oxford Textbook of Critical Care"Oxford University Press.. 3 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Koyama K,Kohda Y,Akuzawa H et al: "Pharmacokinetics of Glufosinate in Rabitts."J Jpn Assoc Acute Med. 9. 556-557 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Koyama K: "The Poisoning Caused by an Herbicide Containing Glufosinate as a Main Component"Igakuno Ayumi. 185. 192-193 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hirose Y,Kobayashi M,Koyama K et al: "A Toxicokinetic Analysis in a Patient with Acute Glufosinate Poisoning."Hum Exp Toxicol. 18. 305-308 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takahashi H,Toya T,Matsumiya N,Koyama K: "A Case of Diabetes Insipidus Associated with Poisoning by a Hebicide Containing Glufosinate"Clinical Toxicology. 38. 153-156 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Koyama K: "Diagnosis, Type, and Severity of Poisoning by Aricultural Chemicals"Internal Med. 85. 1625-1628 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Koyama K: "Glufosinate(BASTA^<【○!R】>)"Jpn J Acute Med. 25. 141-143 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Koyama K: "Poisoning by Glufosinate and a Surfactant"Today's Therapy 1999, ed.by Takasu Y and Ogra E.Igaku-Shoin, Tokyo. 120-122 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Koyama K: "Pesticides and Agricultural Chemicals"Oxford Textbook of Critical Care, ed.by Webb AR,Shapiro MJ,Singer M,and Suter P.Oxford University Press, Oxford. 657 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takahashi H, Toya T, Matsumiya N and Koyama K.: "A case of transient diabetes insipidus associated with poisoning by a herbicide containing glufosinate."Clinical Toxicology. 38. 153-156 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 小山完二: "農薬中毒の診断基準.病型分類.重症度"内科. 85. 1625-1628 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 小山完二(多賀須幸男,尾形悦郎 編): "今日の治療指針(担当部分題目:グルホシネートと界面活性剤による中毒)"医学書院. 3 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hirose Y, Kobayashi M, Koyama K, et al: "A Toxicokinetic Analysis in a Patient with Acute Glufosinate Poisoning"Hum. Exp. Toxicol.. 18. 305-308 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小山完二.石沢淳子.阿久沢尚士: "除草剤を中心とした農薬による中毒の動向-剤型ならびに流通から見た発生要因の検討"医学のあゆみ. 190. 1039-1043 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Koyama K: "Glufosinate and a Surfactant: Which Component Produces Effects on the Central Nervous System in Acute Oral BASTA Poisoning?"Vet. Hum. Toxicol.. 41. 341-341 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kanji Koyama: "(in Oxford Textbook of Critical Care)pesticides and agricultural chemicals"Webb AR,Shapiro MJ,Singer M,Suter P.(Oxford University press). 3(自著分) (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小山完二,幸田幸直,阿久沢尚士,他: "グルホシネートの薬物動態-ウサギを用いた基礎的検討" 日本救急医学会雑誌. 9. 556-557 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小山完二: "グルホシネートを主成分とする除草剤による中毒" 医学のあゆみ. 185. 192-193 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小山完二: "グルホネートを主成分とする除草剤による中毒" 日本病院薬剤師会雑誌. 35. 67-69 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小山完二: "今日の治療指針(医学書院)" 多賀須幸男,尾形悦郎, 3 (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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