| Project/Area Number |
10672163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
応用薬理学・医療系薬学
|
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| Research Institution | Kansai Medical University |
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Principal Investigator |
HATTORI Naoki Kansai Medical University, Department of Pharmacology, Assistant Professor, 医学部, 講師 (80288828)
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Kaori Kansai Medical University, Department of Pharmacology, Research Associate, 医学部, 助手 (10165813)
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| Project Period (FY) |
1998 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | chloride ion / brain / ammonia / anion exchanger / protein kinase C / クロライドイオン / PKC / 海馬培養神経細胞 / 陰イオン交換輸送体 |
|---|
| Research Abstract |
Mechanisms of ammonia-induced increases in neuronal [ClィイD1=ィエD1]i
A neurotoxic factor in hepatic encephalopathy, ammonia (2 mM, 48 hr), increased [ClィイD1-ィエD1]i in cultured rat hippocampal neurons. The increase was found to be due to enhanced expression of anion exchanger (AE3) mediated by protein kinase C activation.
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