| Project/Area Number |
10672185
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | SHOWA UNIVERSITY |
|---|
Principal Investigator |
KAETSU Sachiyo School of Medicine, SHOWA UNIVERSITY assistant, 医学部, 助手 (40255766)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Yasusi School of Medicine, SHOWA UNIVERSITY subprofessor, 医学部, 助教授 (30138490)
GOMI Kunihide School of Medicine, SHOWA UNIVERSITY professor, 医学部, 教授 (60053980)
福地 邦彦 昭和大学, 医学部・臨床病理, 講師 (70181287)
|
|---|
| Project Period (FY) |
1998 – 2000
|
| Project Status |
Completed (Fiscal Year 2000)
|
| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
|---|
| Keywords | Bcl-2 / Bcl-XL / Bax / APOPTOSIS / p53 / Bad / PKB / AKT / caspase 3 / cisplatin / caspase / CDDP |
|---|
| Research Abstract |
Bax and Bad is known as proapoptotic protein. When they are heterodimerized with Bcl-2 or Bcl-XL which s known as anti-apoptotic protein, apoptosis is proceed. But when cells are receaved with some stress of proliferation, Bax and Bad are separated and Bcl-2/Bcl-XL are made anti-apoptotic homodimerizons, cells are proliferated. Our study 1) detection of Bcl-2 family protein and mRNA, p53 protein and caspase 3, 2) When we use anti-cancer drugs, we analuzed Bcl-2 family protein using cell line.
|
