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Reference of new hereditary factors for rheumatoid arthritis

Research Project

Project/Area Number 10672192
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKansai Medical University

Principal Investigator

MASUDA Midori  Kansai Medical University, Departments of Clinical Science and Laboratory Medicine, Associate Professor, 医学部, 講師 (50173753)

Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsrheumatoid arthritis / autoimmune neutropenia / osteoarthrosis / atherosclerosis / FCγRIIIB / FcγRIIA / FcγRIIIA / polymorphism / genotype / 可溶性FcγR / リンパ球機能
Research Abstract

Allelic variants of FcγR confer distinct phagocytic capacities providing a mechanism for heritable susceptibility to immune complex disease. Human FcγRIIa has two codominantly expressed alleles, R^<131> and H^<131>, which differ substantially in their ability to ligate human IgG2. Human FcγRIIIa has two alleles, F^<158> and F^<158>, which differ to ligate human IgG1 and IgG3. Human FcγRIIIb has two expressed alleles, NA1 and NA2, which differ to ligate human IgG3.
The distributions of allelic variants of FcγR in seeral desease were significantly different from those of healthy Japanese donors. The genotype of FcγRIIIB may affect desease activity of rheumatoid arthritis. The genotype of FcγRIIIB and FcγRIIA may affect the production of neutrophil specific auto-antibodies in autoimmune neutropenia of infancy and influence its clinical course. The genotype of FcγRIIIA may affect desease activity of osteoarthrosis. The genotype of FcγRIIIA and FcγRIIIB may affect desease activity of atherosclerosis.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Midori Masuda, et al.: "Induction of Fcγ RII (CD32)-FcRγ-chain association by ouabain in a monocytic cell line THP-1."10th International Congress of Immunology,(G.P.Talwar, et al., eds.),Italy : Monduzzie Editore. 329-333 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 桝田緑,中村伸: "Tissue factorの受容体機能-培養単球におけるFcRγ鎖との会合-"血液アゴラ. 5. 61-67 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 桝田緑: "FcγレセプターIIal."臨床免疫. 32. 657-661 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.Taniuchi, M.Masuda, et al.: "Two cases of autoimmune neutropenia in infants possibly induced by β-lactam antibiotics."J.Pediatr.Hematol.Oncol.. 22. 533-538 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.Taniuchi, M.Masuda, et al.: "Fcγ RIIIb and Fcγ RIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimune neutropenia of infancy."Human Immunol.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Midori Masuda, et al.: "Induction of FcγRII (CD32) -FcRγ-chain association by ouabain in a monocytic cell line THP-1."10th International Congress of Immunology, (G.P.Talwar, et al, eds.), Italy : Monduzzie Editore. 329-333 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Midori Masuda, Shin Nakamura.: "Function of tissue factor as receptor.-Association of tissue factor with FcRγ-chain in cultured human monocytes.-"Blood Agora. 5. 61-67 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Midori Masuda.: "Fcγ receptor IIa1."Clin.Immunol.. 32(6). 657-661 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shoichiro Taniuchi, Midori Masuda, et al.: "Two cases of autoimmune neutropenia in infants possibly induced by β-lactam antibiotics."J.Pediatr.Hematol.Oncol.. 22(6). 533-538 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shoichiro Taniuchi, Midori Masuda, et al.: "FcγRIIIb and FcγRIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimune neutropenia of infancy."Human Immunol.. (in press.).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary

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Published: 1999-04-01   Modified: 2016-04-21  

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