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Analysis of newborn airway aspirate and colostrum collected by midwives : Judging the mother-child health status and influences on nursing care.

Research Project

Project/Area Number 10672242
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical nursing
Research InstitutionThe University of Tokushima

Principal Investigator

TERAO Toshiko  Department of Nursing, School of Medical Sciences, The University of Tokushima, Professor, 医療技術短期大学部, 教授 (90217414)

Co-Investigator(Kenkyū-buntansha) YOSHINAGA Sumiko  Department of Nursing, School of Medical Sciences, The University of Tokushima, Lecturer, 医療技術短期大学部, 助教授 (30227425)
YASUOKA Susumu  Department of Nursing, School of Medical Sciences, The University of Tokushima, Professor, 医療技術短期大学部, 教授 (30035414)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordsnewborn airway aspirate / preterm infants / SP-A / respiratory distress syndrome / BLF / BALF / human airway trypsin-like protease / S-IgA / 肺サーファクタント / 低出生体重児 / s-IgA / 新生児 / 気道吸引液 / 肺表面活性物質 / 生化学的分析
Research Abstract

1 The NAA SP-A level and the ratio of the SP-A level to the total protein level in NAA (the TP ratio) both tended to be lower among neonates born after shorter gestational ages, and they were particularly low among neonates with respiratory distress syndrome (RDS). NAA contains human airway trypsin-like protease (HAT), which is thought to be involved in the physiological functions of the airway, we biochemically analyzed trypin-like enzymes contained in NAA.
2 We measured contents of tracheobronchial and alveolar components contained in the newborn airway aspirates (NAA) obtained from 30 normal newborns, with bronchoalveolar lavage fluid (BALF) and bronchial lavage fluid (BLF) from healthy adults as controls. NAA may be useful for diagnosing pathologic conditions in the airway of the newborns, and for comparing the biological defense mechanism between newborns and adults.
3 To examined NAA's relationship to maternal factors during pregnancy and in the peri-labor period, and neonatal factors. None of the neonatal factors ana differed significantly between the two groups.
4 NAA are useful samples for clinical diagnosis of newborn respiratory disorders, the pulmonary surfactant (PS) content in NAAs from 19 term infants without respiratory problems (Group I) was compared with those from 14 preterm infants (Group II) and 3 infants with respiratory distress syndrome (RDS, Group III).

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 寺尾紀子: "新生児気道吸引液の診断的意義"徳島大学大学院修士論文. 1-18 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 原田江梨子: "新生児気道吸引液と成人気道洗浄液の気道粘液と肺サーファクタントアポタンパク含量の比較"J.Jpn.Med.Soc.Biol.Interface. 31. 33-40 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 寺尾紀子: "新生児気道吸引液の成分分析とその関連要因の検討"徳島大学医療技術短期大学部看護学科集録.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 寺尾紀子: "正常新生児と早産児の新生児気道吸引液の肺サーファクタントアポタンパク、SP-Aの分析"J.Jpn.Med.Soc.Biol.Interface. 31. 41-48 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Toshiko Terao.: "Diagnostic value of newborn airway aspirate : Analysis of active substances on the lung's surface and of proteases."Department of Mathematical and Natural Sciences, Faculty of Arts and Sciences, The University of Tokushima, (Treatise Master). 1-18 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Eriko Harada.: "Comparison of airway mucus and pulmonary surfactant- associated protein contents of newborn airway aspirates with those of lavage fluids from adult airways"J.jpn.Med.Soc.Biol.Interface. 31. 33-40 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Toshiko Terao.: "Analyses of the components of newborn airway aspirate and related factors : With special reference to maternal factors pertaining to pregnancy and labor and neonatal factors."Dept.of Nursing, School of Medical Sciences, Univ Tokushima, kanngosyuuroku. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Toshiko Terao.: "Analysis of the pulmonary surfactant-associated protein, SP-A in newborn airway aspirates from term and preterm infants"J.jpn.Med.Soc.Biol.Interface. 31. 41-48 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 寺尾紀子: "正常新生児と早産児の新生児気道吸引液の肺サーファクタントアポタンパク、SP-Aの分析"J.Jpn.Med.Soc.Biol.Interface. 31. 41-48 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 原田江梨子: "新生児気道吸引液と成人気道洗浄液の気道粘液と肺サーファクタントアポタンパク含量の比較"J.Jpn.Med.Soc.Biol.Interface. 31. 33-40 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Toshiko Terao,Eriko Harada,Sumiko Yoshinaga,Fumiko Michishige,Akiko Kitamura,Susumu Yasuoka: "Analysis of pulmonary surfactant-associated protein,SP-A in newborn airway aspirates from healthy and low birth weight infants"第35回界面医学会誌. 28-29 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Eriko Harada,Toshiko Terao,Sumiko Yoshinaga,Fumiko Michishige,Akiko Kitamura,Susumu Yasuoka: "Comparison of airway mucus and pulmonary surfactant-associated protein contents of newborn airway aspirates with those of lavage fluids from adult airway"第35回界面医学会誌. 26-27 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Susumu Yasuoka,Sumiko Yoshinaga,Fumiko Michishige,Eriko Harada,Toshiko Terao: "Precursor of human airway trypsin-like protease is type II integral membrane protein"第35回界面医学会誌. 44-45 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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