Immunoregulatory function and its mechanism of food components
| Project/Area Number |
10680148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
食生活
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| Research Institution | Jissen Women's University |
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Principal Investigator |
AOKI Yosuke Professor, Department of Food and Health Sciences, Faculty of Human Life Sciences, Jissen Women's University., 生活科学部・食生活科学科, 教授 (80049030)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | biophylaxis / medullasin / cathepsin G / granulocytes / NK cell / green tea / 生体防御能 / スタノール / プロテアーゼ / 腸管出血性大腸菌 / Stx2 / NK活性 / リンパ球 |
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| Research Abstract |
In order to clarify the effect of food components on immune functions, their effect on neutral proteases such as medullasin and cathepsin G in granulocytes was studied, because both medullasin and cathepsin in granulocytes were shown to be engaged in the regulation of biophylaxis. We found that cathepsin G also enhances natural killer (NK) cell activity by acting directly on NK cells. Addition of docosahexaenoic acid to the diet of mice caused the increase of medullasin activity in granulocytes dose-dependently, to the contrary, saturated fatty acids such as palmitic acid and stearic acid decreased medullasin activity in granulocytes. These results indicate that fatty acid in the diet may influence biophylactic activity. Addition of green tea leaf to the diet of mice decreased both medullasin and cathepsin G activity in granulocytes. To the contrary, green tea extract in the diet of mice increased both protease activities in granulocytes. These results indicate that certain components in green tea increase or decrease these neutral protease levels in granulocytes resulting in the regulation of biophylaxis in vivo.
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Report
(4 results)
Research Products
(20 results)
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[Publications] K.Fukai, D.Tsuruta, M.Chanoki, H.Kobayashi, S,Someta, K.Nakagawa, S,Taniguchi, M,Ishii, Y,Aoki.: "Medullasin and inflammatory skin diseases (in Japanese)"Hifu. 40. 122-125 (1998)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Aoki, Y., Saida, T., Nakano, I., Saito, T., Ikeguchi, K., Urabe T., Nishiguchi, E., Suzuki, H., Takahashi, K., Katsuragi, H., Mizuno, Y.: "Medullasin levels in granulocytes of patients with multiple sclerosis. A clinical parameter for the diagnosis of multiple sclerosis."Acta Neurologica Scand.. 102. 218-221 (2000)
Description
「研究成果報告書概要(欧文)」より
Related Report
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