| Project/Area Number |
10680740
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Toyama Medical and Pharmaceutical University |
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Principal Investigator |
FUKUDA Masaji Toyama Med.& Pharmaceut.Univ.Behav.Science Professor, 医学部, 教授 (60126547)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Amygdala / Fear / Emotion / Behavior / Hippocampus / Rats / Amydala / Neural Information |
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| Research Abstract |
(1) Effects of Amygdala Central Nucleus Lesions on Heart Rate in Psychological Stress using the communication box
The heart rate of shock-free animal in the central compartment decreased during the conditioned tone when the animal was motionless, but increased when the animal was moving. When these animals directly received footshocks, their heart rate increased during the conditioned tone and remarkably after footshock even during motionless periods. Changes of heart rate in shock-free and shocked animals were suppressed during the conditioned tone and post-stimulation phase by the amygdala lesion.
(2) Neuronal responses of rat amygdala in fear startle potentiation
Of 148 neurons recorded, 39 (26.4%) responded during the conditioned stimulus (CS) and startle stimulus in the conditioned animals. 33 neurons responded to the CS.Response during the CS was modulated by signal that indicated inhibition of conditioned responses. The magnitude of startle potentiation was correlated with neuronal responsiveness during the CS phase.
(3) Amygdala neuron responses to prepulse inhibition during rat startle behavior
Of 335 amygdalar neurons recorded, 100 (29.9%) responded during such a startle behavior. Of these, 76 (22.7%) responded at all of noise-alone trials and prepulse trials of 1 and 12 dB above the background noise. Twenty-four neurons responded differentially during prepulse trials.
(4) Amygdala contributions in conditioned place avoidance
We developed a new fear conditioning task to study cue-related fear and contextual fear, in which the unconditioned stimulus of electrical shock is related to a certain place. The animal is able to learn the place-fear association task within several application of electrical shock. Ibotenic lesion of the central and basolateral nuclei induced revisiting in the shock area that he received it previously.
These suggest that the amygdala plays an important role of fear recognition fear memory and fear expression.
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