| Project/Area Number |
10680791
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ICHINOSE Shizuko Tokyo Medical and Dental University, Instrumental Analysis Research Center for Life Science, assistant professor, 機器分析センター, 助手 (60014156)
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| Co-Investigator(Kenkyū-buntansha) |
MUNETA Takeshi Tokyo Medical and Dental University, Department of Orthopaedic Surgery, Lecturer, 医学部, 講師 (50190864)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | Biomaterial / Total knee prosthesis / Toxicity / Co-Cr-Mo alloy / Ti-Al-V alloy / Wear particle / Dissolution / Electron microscopic observation / 毒性の発現 / 合金微粒子とイオン化 / マクロファージ / Co-Cr合金 |
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| Research Abstract |
We surgically obtained two Co-Cr-Mo and five Ti-Al-V alloy knee prosthesis which were retrieved due to mechanical failure and pain. We examined the distribution and the size of the small particles which were released from Co-Cr-Mo and Ti-Al-V alloy using backscattered SEM and TEM. In addition we analyzed the metal ions in the adjacent tissues of the knee prosthesis by energy dispersive X-ray spectroscopy(EDS).
We observed that small particles were detected evenly in the synovial tissues and the particles contained Co-Cr-Mo and Ti-Al-V alloy components. Metallic wear particles were phagocyted by the cells next to the synovial bursae and showed bulky or needle-like structures. We demonstrated that both Co-Cr-Mo particles and Cr particles were present in the cells adjacent to Co-Cr-Mo alloy, although Ti-Al-V particles alone were found in cases using Ti-Al-V alloy prosthesis. These results suggest that Co ion released from Co-Cr-Mo alloy enters the surrounding tissues as well as blood stream and damages the body.
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