THE DEVELOPMENT OF DELIVERY DEVICE FOR INHALED NITRIC OXIDE IN THE LONG-TERM USE

Research Project

Project/Area Number	10680802
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Biomedical engineering/Biological material science
Research Institution	Kitasato University
Principal Investigator	HIROSE Minoru. Dept. of Clinical Engineering, Kitasato University of Allied Health Sciences, Lecturer, 医療衛生学部, 講師 (50286382)
Co-Investigator(Kenkyū-buntansha)	WATANABE Satoshi Dept. of Clinical Engineering, Kitasato University of Allied Health Sciences, Professor, 医療衛生学部, 教授 (40050463) KOBAYASHI Hirosuke Dept. of Clinical Engineering, Kitasato University of Allied Health Sciences, Lecturer, 医学部, 講師 (70153632) 古垣達也北里大学, 医療衛生学部, 助手 (60306644)
Project Period (FY)	1998 – 1999
Project Status	Completed (Fiscal Year 1999)
Budget Amount *help	¥1,200,000 (Direct Cost: ¥1,200,000) Fiscal Year 1999: ¥300,000 (Direct Cost: ¥300,000) Fiscal Year 1998: ¥900,000 (Direct Cost: ¥900,000)
Keywords	Inhaled nitric oxide / nitric oxide (NO) / Chronic respiratory failure / Home oxygen therapy / Delivery device / Pulmonary hypertension / 酸素セーバー
Research Abstract	We developed two kinds of delivery devices, a breathing interval dependence type and a gas supply time setup type, for inhaled nitric oxide (INO) in the long-term use, for the purpose of the prevention of the cor pulmonale in the chronic respiratory failure patient. The trial experimental devices improve oxygen saver of the existing being used for home oxygen therapy. The performance test of the device (breathing interval dependence type) was tested by breathing simulation. As the result, the change of NO concentration versus tidal volume was close to the theory value. But the change of NO concentration versus breathing rate made a difference with the increase in the breathing rate. There was a little consumption of the NO gas in this device, it was easy, it can be used for the safety, the occurrence of NOィイD22ィエD2 is very low. We think about that the trial experimental devices turn to practical use. The result of this research was announced in the Japanese medical instrumentation meeting and Japanese medical electronics and biological engineering meeting.