| Project/Area Number |
10836022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
自然史科学
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
TATENO Yoshio National Institute of Genetics, Center for Information Biology, Professor, 生命情報研究センター, 教授 (00202424)
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| Co-Investigator(Kenkyū-buntansha) |
KAWANISHI Yuichi FUJITSU LIMITED, Science Systems Division, Researcher, 科学システム統括部, 研究職
FUKAMI Kaoru (KOBAYASHI) National Institute of Genetics, Center for Information Biology, Assistant professor, 生命情報研究センター, 助手 (20225494)
GOJOBORI Takashi National Institute of Genetics, Center for Information Biology, Professor, 生命情報研究センター, 教授 (50162136)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1998: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Natural history / Molecular evolution / Structural evolution / HLA / Genome / Operon / Mitochondria / Periplasmic binding protein / MIC / ゲノム断片重複 / LINE / エポキシダーゼ / プロテオーム / 色素遺伝子 / ゲノム比較 / ゲノム進化 / SINE / periplasmicタンパク / 高次構造進化 / 分子系統 / ミトコンドリア進化 |
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| Research Abstract |
We have carried out research in the following topics in the past two years with the view that a gene is composed of sub-units each of which corresponds to a structural or a functional unit of a protein and thus is considered to be an evolutionary unit of a gene.
1. Evolutionary dynamics of a HLA genome region,
2. Evolution of operons by comparison of the whole bacterial genome,
3. Estimation of evolutionary rate over the whole E, coli genomes,
4. Phylogeny of vertebrates on the basis of the whole mitochondrial genomes,
5. Structural evolution of periplasmic binding proteins,
6. Evolution of acetylcholin receptor units,
7. Discovery of a new gene in eukaryote by proteome analysis,
8. Evolution of the pigment synthesis system in ascidian,
9. Database design for genome datat,
10. Database management system for genome sequences.
These topics do not seem be related each other at first glance. However, one can categorize 1,2,3 and 4 into genome evolution, 5 and 6 into evolution of functional and structural units, 7 and 8 into evolution of a genome as an interrelated complex of genes and non-genes, and 9 and 10 into genome databases. I strongly believe that those research outcomes will contribute to the study of natural history of genomes.
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